Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Centaurus Biopharma Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

University of Science and Technology Beijing

Shouyao Holdings (beijing) Co., Ltd.

Centaurus Biophrama Co., Ltd.

Shouyao Holdings Co., Ltd.

Yinghui Sun

Yongxin Han

Hong Luo

Yong Peng

Yuandong Hu

Fansheng Kong

Li Zhu

Ling Yang

Dengming Xiao

Liguang Dai

Xiaowei Duan

Hongjiang Xu

Na Zhao

Yan Zhu

Shanchun Wang

Xijie Liu

Yanqing Yang

Huting Wang

Jijun Li

Zanping Wang

Yu Wang

Hui Zhang

Zhe Wang

Wei Wu

Zhihua Liu

He Wang

Qiong Wu

Fei Liu

Xin Tian

Zhi Liang

Honghao Yu

Ying Sun

Yizhong Zhu

Xinhe Xu

Meng Guo

Chang Lu

Chuanyu Zhang

Rong Yu

Xianxing Shang

Quan Hu

Qin Yan

Zhaobai Zhong

Rongming Wang

Bingxu Liu

Weinan He

Yeliu Wang

Yongheng Wei

Jian Sun

Xiaofeng Zhai

Hongjuan Li

Jiuqing Zhang

Yangjian Liu

Baokun Yuan

Wangyang Min

Jinsuo Yao

Deng Hou

Nan Jiao

Yeling Ji

The present invention relates to a iminosulfanone compound represented by formula (I) as a bromodomain protein inhibitor and a pharmaceutically acceptable salt thereof and to a preparation method, pharmaceutical composition, and medical use thereof.

Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof

In the field of photoelectric devices, a visible light detector is provided with high-photoresponse based on a TiO/MoSheterojunction and a preparation method thereof. The detector, based on a back-gated field-effect transistor based on MoS, includes a MoSchannel, a TiOmodification layer, a SiOdielectric layer, Au source/drain electrodes and a Si gate electrode, The TiOmodification layer is modified on the surface of the MoSchannel. By employing micromechanical exfoliation and site-specific transfer of electrodes, the method is intended to prepare a detector by constructing a back-gated few-layer field-effect transistor based on MoS, depositing Ti on the channel surface, and natural oxidation.

Visible light detector with high-photoresponse based on TiO/MoSheterojunction and preparation thereof

The present application relates to a macrocycle containing aminopyrazole and pyrimidine, which is represented by formula (I), a pharmaceutical composition thereof, and a use thereof in inhibiting tropomyosin receptor kinase (Trk) activity and in treating diseases in mammals that are mediated by Trk. 

Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof

Provided is an amino pyrazolopyrimidine compound as represented by the following structural formula used as a neurotrophic factor tyrosine kinase receptor inhibitor. The compound can inhibit the activity of Trk kinase and can treat diseases mediated by a Trk tyrosine kinase receptor in mammals. 

Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor

A pyrrolopyrimidine comprising a cyclopentyi substituent. The present invention specifically relates to a compound represented by formula. A and a stereoisomer and pharmaceutically acceptable salt thereof. The invention further relates to a method for manufacturing the pyrrolopyrimidine comprising the cyclopentyl substituent represented by formula A, a pharmaceutical composition, and an application of the compound in treating a disease induced by Janus kinase. 

Pyrrolopyrimidine comprising cyclopentyl substituent

The present application relates to the field of pharmaceutical chemistry, and in particular, to a pyrrolopyrimidine compound represented by general formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for preparing the pyrrolopyrimidine compound represented by general formula (I), pharmaceutical compositions and an application of the pyrrolopyrimidine compound in treating diseases mediated by Janus Kinase. 

Pyrrolopyrimidine compound

The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans. 

Inhibitors of bruton's tyrosine kinase

The present invention discloses substituted 2-aminopyridine derivatives as protein kinase inhibitors; specifically, the invention relates to 2-aminopyridine derivatives having protein kinase inhibitory properties, their manufacture, pharmaceutical compositions containing them, and use of the compounds and the pharmaceutical compositions thereof for the treatment of diseases associated with protein kinase.

Substituted 2-aminopyridine protein kinase inhibitor

The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition. 

Kinase modulating compounds, compositions containing the same and use thereof

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Beijing, China

Yinghui Sun