Axikin Pharmaceuticals, Inc.

Bayer Aktiengesellschaft

Bayer Schering Pharma Ag

Yingfu Li

Klaus Urbahns

Kevin Bacon

Toshiya Moriwaki

Noriko Nunami

Keiko Fukushima

Nagahiro Yoshida

Hiroko Yoshino

Norihiro Kawamura

Makiko Marumo

Timothy B Lowinger

Naoki Tsuno

Toshiki Murata

Takashi Yoshino

Takuya Shintani

Hiromi Sugimoto

Megumi Yamauchi

Tetsuo Kikuchi

Akihiko Watanabe

Kentaro Hashimoto

Roger Astbury Smith

Chengzhi Zhang

Jacques P Dumas

William Johnston Scott

Muneto Mogi

Qian Zhao

Martha E Rodriguez

Margaret Ann Popp

Jason A Duquette

Ming Wang

Noriyuki Yamamoto

Dongping Fan

Takeshi Yura

Hiroshi Komura

Toshio Kokubo

Timothy Lowinger

Scott Miller

Arnel B Concepcion

Georgiy Bondar

Gyoonhee Han

Aniko M Redmann

Yoshino Hiroko

Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.

2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of inflammatory or immunological disorders

The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders

This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer.

Heterocycles

Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; Rrepresents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim

2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

A compound of the formula (I)in which Ris &#x2014;OR, &#x2014;SR, &#x2014;SOR, &#x2014;SOR, &#x2014;NHR, or &#x2014;NRR, and R, R, and Rare as defined broadly in the text. Ris H, C-Calkyl, carbamoyl, or an ester group. Ris thienyl, pyridyl optionally substituted by halogen or C-Calkoxy; naphthyl optionally substituted by C-Calkoxy; dioxane fused phenyl; dioxacyclopentane fused phenyl; or optionally substituted phenyl. Y is CH or N. A process for preparing such compounds, pharmaceutical compositions containing such compounds, and a method of treating asthma using them are also disclosed and claimed.

Imidazopyrimidine derivatives and triazolopyrimidine derivatives

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Hamden, CT, United States of America

Yingfu Li