Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Chinese Academy of Sciences

Medshine Discovery Inc.

Yingchun Liu

Charles Z Ding

Zhaobing Xu

Jian Li

Shuhui Chen

Lihong Hu

Fei Wang

Kai Lin Li

Xiquan Zhang

Guoping Hu

Rui Zhao

Weidong Li

Zongbin Li

Baoping Zhao

Chao Yuan

Qiang Fang

Ruibin Lin

Kaikai Jin

Shen Diao

Bingjie Ren

Xingxun Zhu

Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer. 

SMAC mimetics used as IAP inhibitors and use thereof

A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like. 

Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor

Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor. 

Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug

The present invention belongs to the field of preparation of high performance polymers, and specifically relates to a low dielectric constant polymer containing dinaphthyl and hexafluorocyclobutyl ether units, and preparation method and use thereof. The polymer is prepared as follows: under the effect of an alkali, 1-naphthol bromotetrafluoroethane ether is prepared from 1-naphthol and tetrafluorodibromoethane in an organic solvent, and then reduced by a zinc powder so as to obtain 1-naphthol trifluorovinyl ether. 1-naphthol trifluorovinyl ether is treated at a high temperature to obtain a bisnaphthol hexafluorocyclobutyl ether monomer. The monomer is subjected to oxidative coupling in the presence of ferric trichloride so as to obtain a thermal polymer containing dinaphthyl and hexafluorocyclobutyl structural units with a good film-forming property, and in a nitrogen atmosphere, the temperature for 5% weight loss (T) of the obtained film is 437&#xb0; C., and the carbon residue yield at 1000&#xb0; C. is 54.24%. The dielectric constant (30 MHz) of the film is 2.33. The polymer is suitable for use in the electronic and electrical industries as an insulation coating layer and an encapsulating material for electron components.

Low dielectric constant polymer containing dinaphthyl and hexafluorocyclobutyl ether unit, preparation method and use

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Shanghai, China

Yingchun Liu