Amgen Inc.

Yingcai Wang

Julio Cesar Medina

Jiwen Liu

Jonathan B Houze

Zhihua Ma

Michael J Schmitt

Liusheng Zhu

Zice Fu

Rajiv Sharma

Wang Shen

Ming Yu

Paul John Dransfield

Sean P Brown

Marc Vimolratana

Jinqian Liu

SuJen Lai

Todd J Kohn

XianYun Jiao

Michael G Johnson

Vatee Pattaropong

Hilary Plake Beck

An-Rong Li

Jian Luo

Xuelei Yan

Yosup Rew

Felix Gonzalez Lopez De Turiso

Jason A Duquette

Ana Zurisadai Gonzalez Buenrostro

Zhihong Li

Zhongyu Wang

Jiasheng Fu

Michael W Gribble, Jr

Jiang Zhu

Jeffrey D Reagan

Michelle Akerman

Wei Qiu

Ying Sun

Lawrence R McGee

Frank Kayser

Xiaohui Du

Xiaoqi Chen

Daqing Sun

David John Kopecky

Matthew Irvine Brown

Xiaodong Wang

Jeffrey Thomas Mihalic

Dustin L McMinn

Jonathan Dante Low

Brian M Fox

Michael D Bartberger

John Eksterowicz

Steven H Olson

Brian Stuart Lucas

Richard V Connors

Jeffrey Deignan

Julie Anne Heath

Darin J Gustin

Joel McIntosh

Jian Zhang

Xian Yun Jiao

Yihong Li

Yongli Su

Xin Huang

Philip M Roveto

Benjamin Fisher

Stephen J Shuttleworth

Daniel C H Lin

Qingge Xu

Xi Alan Huang

H Lucy Tang

Alan Martin Allgeier

Joseph F Payack

Xianghong Wang

Alan C Cheng

Mario G Cardozo

Kexue Li

Gayathri Swaminath

Sarah Lively

Mike Elias Lizarzaburu

Jie Zhang

Michael R Degraffenreid

Yunxiao Li

YuMei Xiong

Manuel Zancanella

Joshua Taygerly

Thomas Storz

Jerry A Murry

Margrit Schwarz

Yong-Jae Kim

Xuemei Wang

Mark Grillo

David Karl Bedke

Qiong Cao

Jacqueline E Milne

Janan Jona

Daniel Lin

Li Yang

Matthew Brown

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Compounds that inhibit MCL-1 protein

The present invention provides MDM2 inhibitor compounds of Formula I, 

Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I&#x2032;B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Spirocyclic GPR40 modulators

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Phenyl acetic acid derivatives

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Substituted biphenyl GPR40 modulators

Heterocyclic GPR40 modulators

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Compounds and methods useful for treating asthma and allergic inflammation

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Benzo-fused compounds for use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L, L, M, X, L, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders

Asthma and allergic inflammation modulators

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Fremont, CA, United States of America

Yingcai Wang