Coopervision International Holding Company, LP

Xiamen LP Pharmaceutical Co., Ltd.

LP Pharmaceutical (xiamen) Co., Ltd.

Ying Ye

Yun Zhang

Charlie Chen

Peter P Zhu

Janshon Zhu

Arthur Back

Yuwen Liu

Junhao Ge

Hong Xue

Victoria Rogers

Andrew Luk

Rongbin Ling

Inna Maltseva

Haijian Zhu

Peter Chaoquan Zhu

Hongjin Qiu

Qing Luo

Kathleen Khong

Hongjin Qui

The present invention provides a pharmaceutical composition for delivering palonosetron through the buccal mucosa or sublingual mucosa. The pharmaceutical composition comprises 0.05-35% (w/w) of palonosetron, 40-90% of a film forming agent, 1-10% (w/w) of a plasticizer, 5-25% (w/v) of an adhesive agent, and 0.1-5% of a penetration enhancing agent. A preferred plasticizer is a polysorbate. A preferred adhesive agent is polyvinylpyrrolidone or carboxymethylcellulose. A preferred penetration enhancing agent is peppermint oil or menthol.

Palonosetron oral transmucosal film or patch

The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual mucosa. The present invention provides a method for treating cancer by buccal or sublingual administration of the pharmaceutical composition to a subject. The pharmaceutical composition comprises a taxane, a non-ionic surfactant, a viscosity enhancing agent, an adhesive agent, and an alcohol solvent at pH 4-6.

Transmucosal taxane composition

Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.

Silicone hydrogel contact lenses for sustained release of beneficial polymers

Transmucosal administration of taxanes

A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

Materials for use in ophthalmic applications and methods

A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

Wettable hydrogel materials for use in ophthalmic applications and methods

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Irvine, CA, United States of America

Ying Ye