Colgate Palmolive Company

Ying Yang

Guofeng Xu

Harsh Mahendra Trivedi

James G Masters

Lin Fei

Long Pan

Zhiqiang Liu

Zhigang Hao

Stanislav Jaracz

Michael Prencipe

Michael Stranick

Dandan Chen

James Gerard Masters

Thomas J Boyd

Ravi Subramanyam

Jairajh Mattai

Robert D'Ambrogio

Tao Xu

Paul Joseph Vincenti

LaTonya Kilpatrick-Liverman

Paul Thomson

Shamim Alam Ansari

Jianhong Qiu

Camille Zenobia

Michael A Stranick

Latonya Kilpatrick-Liverman

Shamim Ansari

Surag Mantri

Evangelia Arvanitidou

Shyamala Pillai

Roelof Trip

Davide Miksa

Daniel Mufson

Joe Vazquez

Steven E Miller

Carlo Daep

Peng Yan

Yelloji-Rao K Mirajkar

Cory Anderson

Shao Peng Xu

Cortney L Worrell

Mary Horchos

Chanda Macias

Yanan Hu

Neelima Utgikar

Katherine Hu

Stanistav Jaracz

Geofeng Xu

Xu Guofeng

Dao-Yi Yu

Er-Ning Su

Stephen Cringle

Qing Claire He

Robert D'ambrogio

Hoang Van Nguyen

James Mccrea

Colin Tan

Michael Alan Stranick

Sreedhara Alavattam

An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

Oral health model for high throughput screen and characterization of oral hygiene products

Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; M1F:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.

Biomarkers of neutrophil deregulation as diagnostic for gingivitis

Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individual's oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.

Methods of inducing sIgA and mucin 5b in the oral cavity

This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

Oral care compositions and methods of use

Oral care compositions including a hemostatic agent, wherein the hemostatic agent includes a mixture of oleanic acid and eugenol. Methods of making and using these compositions are also described.

Oral care compositions

An exfoliating dentifrice composition is described that contains a plurality of granules and an orally acceptable vehicle. The granules include at least one polymeric binding agent. The composition includes at least one abrasive agent having an average particle diameter of 0.01 mm to 4 mm. Also included are methods of exfoliating an oral cavity soft tissue by use of the composition.

Dentifrice composition and method of use

The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health. 

Menthol-derivative compounds and use thereof as oral and systemic active agents

The present invention relates to oral care compositions and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm. Disclosed herein are oral care compositions comprising an Amadori compound having a glucose moiety and an amino acid moiety. The Amadori compound has use for inhibiting oral microbial biofilm formation and/or degrading an oral microbial biofilm in the oral cavity of a mammalian subject.

Oral care composition comprising an Amadori compound

The invention provides a personal care composition for application to the skin which comprises a personal care composition for application to the skin or hair comprising a zinc X halide and a cosmetically acceptable base, wherein X is an amino acid or trimethylglycine. Methods of making and using the compositions are also provided. The zinc X halide is can be used to deliver zinc salts to block perspiration and provide antibacterial effects.

Zinc lysine halide complex

A personal care composition for application to the skin or hair comprising a cosmetically acceptable carrier and zinc X halide precursors wherein the precursors are a zinc ion source, an X source, and a halide source, wherein the halide source can be part of the zinc ion source, the X source, or a halogen acid, wherein the precursors can complex into the zinc X halide when the composition is applied to the skin or hair, wherein X is an amino acid or trimethylglycine. Methods of making and using the compositions are also provided. When the precursors complex into a zinc X halide, the complex can be used to deliver zinc salts to block perspiration and provide antibacterial effects.

Composition with zinc amino acid/trimethylglycine halide precursors

Described herein are oral care compositions comprising a mixture of zinc oxide and trimethylglycine, in free or orally acceptable salt form. Methods of making and using the compositions are also provided.

Oral care products comprising zinc oxide and trimethylglycine

The invention provides oral care compositions comprising a mixture of tetrabasic zinc halide and trimethylglycine, in free or orally acceptable salt form. Methods of making and using the compositions are also provided.

Oral care products comprising tetrabasic zinc chloride and trimethylglycine

Described herein are compositions comprising isopropyl magnolol; a surfactant system; and an orally acceptable carrier, together with methods of making and using the same.

Described herein are oral care compositions comprising a tetrabasic zinc halide and an amino acid; along with methods of making and using the same.

Oral care products comprising a tetrabasic zinc-amino acid-halide complex

Growing community of inventors

Monmouth Junction, NJ, United States of America

Ying Yang