Amgen Inc.

Ying Sun

Julio Cesar Medina

Jonathan B Houze

Liusheng Zhu

Zhihua Ma

Rajiv Sharma

Jiwen Liu

Yingcai Wang

Michael J Schmitt

Jian Luo

Jian Zhang

Jinqian Liu

Stephen J Shuttleworth

Daniel C H Lin

Wei Qiu

Michelle Akerman

Jeffrey D Reagan

Jinqain Liu

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and Rhas the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders

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Albany, CA, United States of America

Ying Sun