Waters Technologies Corporation

Ying Qing Yu

Martin Gilar

Bruce J Compton

John Charles Gebler

Robert Birdsall

Edouard S Bouvier

Peter J Lee

Elizabeth K Kane

Jacob Kellett

The present technology relates to a method of analyzing a sample including an analyte. The method includes injecting the sample including the analyte into a mobile phase. The mobile phase includes a metal chelator additive having a concentration between about 1 ppm to about 10 ppm. The method also includes separating the analyte using liquid chromatography and analyzing the analyte using a mass spectrometer, an ultra-violet detector, or a combination thereof.

RPLC-based peptide mapping chromatographic performance using metal chelators as mobile phase additives

The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

Destructible surfactants and uses thereof

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Uxbridge, MA, United States of America

Ying Qing Yu