Telefonaktiebolaget Lm Ericsson (publ)

Tsinghua University

Capitalbio Corporation

Biocells (beijing) Biotech Co., Ltd.

Applied Pharmaceutical Science, Inc.

Ying Lu

Jiang He

Baifeng Cui

Wei Sun

Libin Liu

Hao Wang

Wanli Xing

Shuo Yang

He Yan

Yun Zhi Lin

Jinfeng Zhao

Jun Zhong

Huamin Han

Yongbo Liu

Xiaohu Chen

A nitrogen-containing polycyclic fused ring compound of formula I, a pharmaceutical composition thereof, a preparation method therefor and use thereof are related to the field of medicinal chemistry. The compound can be used as a selective and effective RET inhibitor. It has strong inhibitory effect on the RET gatekeeper residue mutant RET V804M, RET solvent-front residue mutant RET G810R and other clinically relevant RET mutants, as well as RET wt. The compound can also inhibit the growth of TT cell line derived from thyroid cancer and Ba/F3 cells transformed with various RET mutants, and induce the death of TT cells.

Nitrogen-containing polycyclic fused ring compound, pharmaceutical composition thereof, preparation method therefor and use thereof

A method of enriching nucleic acid, including mixing a sample with a solid phase extraction material; and separating the solid phase extraction material; wherein the solid phase extraction material is glass beads or magnetic beads modified with reduced graphene oxide. Also disclosed is a method of detecting nucleic acid, including mixing a nucleic acid sample enriched by the method above with a probe; and amplifying and detecting an amplification product by electrophoresis.

Solid phase extraction material and its use for nucleic acid enrichment and detection

The present disclosure provides a method () in a network node advertising a Binding Segment Identifier, BSID. The method () includes: receiving () a first echo request packet containing a first target Forwarding Equivalence Class, FEC, stack including an FEC associated with the BSID; and transmitting (), in response to a Time To Live, TTL, expiration associated with the first echo request packet, a first echo reply packet to an initiating network node initiating the first echo request packet, the first echo reply packet containing an indicator indicating that the FEC is to be replaced by a set of FECs.

Method and network node for label switched path traceroute

There is provided in the present application a peptide comprising the amino acid sequence of YEKLLDTEI (SEQ ID NO: 1) or a functional variant thereof. The peptide is an active peptide for the treatment of a central nervous system injury. The present application also provides a chimeric peptide comprising an active peptide and an internalization peptide. The present application also provides a pharmaceutical composition comprising the active peptide or the chimeric peptide, as well as medical use of the active peptide or the chimeric peptide.

Therapeutic peptides for excitatory neurotoxicity-related injuries

The disclosure relates to a method of LSP number planning in an inter-chassis device comprising a plurality of peers. In one embodiment, the method comprises steps of generating an LSP and transmitting the generated LSP outside at a peer. The LSP number in the generated LSP is a number in a number range assigned to that peer. The number ranges assigned to different peers of the inter-chassis device do not overlap with each other. By the LSP number planning method, the peer may discover automatically other peers in the same inter-chassis, and announce itself independently.

Inter-chassis peer and method used therein

A method and apparatus for managing a media access control address are provided. The method comprises assigning a priority to the MAC address. The method also comprises managing the MAC address in a forwarding database based on the priority. With the method and apparatus, a MAC flooding attack can be efficiently avoided and communication performance would be improved in a secure manner.

Method and apparatus for managing media access control addresses

Growing community of inventors

Beijing, China

Ying Lu