Novartis Vaccines & Diagnostics, Gmbh

Other

Universaity of Stellenbosch

Ying Lian

Susan Barnett

Jan Zur Megede

Karin Hartog

Susan Engelbrecht

Mark J Selby

Christopher I Walker

Hong Liu

Indresh K Srivastava

Catherine Greer

Thomas J Scriba

Estrelita Janse Van Rensburg

Estrelita Janse Van Rensberg

Susan W Barnett

Thomas Jens Scriba

The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polypeptides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

HIV-1 south african subtype C env proteins

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.

Expression of HIV polypeptides and production of virus-like particles

The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.

Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2

The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.

Expression cassettes encoding modified human immunodeficiency virus type 1 subtype C envelope glycoproteins

The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof

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Albany, CA, United States of America

Ying Lian