Qilu Pharmaceutical Co., Ltd.

Ying Li

Long Zhang

Jianrong Zhu

Zongru Guo

Minghui Zhang

Chuanwen Fan

Qingmin Yang

Shousheng Yan

Zhongru Guo

Shaobo Yang

The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors. 

4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors

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Gansu, China

Ying Li