Tci Co., Ltd.

Taiwan Bio-Manufacturing Corporation

Ying-Ju Chen

Chin-Hsiu Yu

Hsiang-Ling Su

Chao-Yi Teng

A chimeric signal peptide for protein expression includes an N-region, a hydrophobic region, and a C-region, wherein the N-region and the C-region are from a same signal peptide of a first protein and the hydrophobic region is from a signal peptide of a second protein, wherein the first protein is different from the second protein. The first and second protein are independently selected from the group consisting of BM40, IL2, HA, Insulin, CD33, IFNA2, IgGK leader, AZU, and SEAP.

Chimeric signal peptides for protein production

Provided is a method for enhancing collagen secretion and preventing cutaneous aging usingextract. Theextract includes active ingredients that are able to effectively enhance the ability of collagen secretion of dermal fibroblasts as well as prevent the glycation of collagen and resist the damage of ultraviolet light exposure. The preparation of theextract is environmental friendly and is able to promote the economic value of; thus, the present invention is suitable for applications in the development of food products, especially beverages, skin care and cosmetic products.

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Taipei, Taiwan

Ying-Ju Chen