Chung Yuan Christian University

National Defensive Medical Center

Ying-Ju Chen

Tzong-Yuan Wu

Chang-Chi Lin

Szu-Cheng Kuo

Mean-Shine Chen

Chao-Yi Teng

Tsu-An Hsu

Shin-Ru Shih

Suey-Sheng Kao

Yi-Ting Lin

Chien-Ling Su

Tzyy-Rong Jinn

Der-Jiang Chiao

Pei-Yun Shu

Shu-Fen Chang

Shin-Jhan Zeng

Yu-Ming Wang

Chung-Hsiung Wang

Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.

Method of detecting antibodies against JEV or ZIKV using recombinant baculoviruses expressing prM/e

Recombinant baculoviruses and their uses in detecting arthropod-borne virus

Disclosed herein is a method for the treatment of an infection with, or disease caused by, Chikungunya virus in a subject. The method includes administering to the subject a therapeutically effective amount of suramin as the active agent.

Method for treating Chikungunya virus infection

Disclosed herein is a recombinant viral construct and its uses thereof. The recombinant viral construct is capable of simultaneously expressing three exogenous proteins, including a classical swine fever virus (CSFV) antigen, a porcinetype 2 (PCV2) antigen, and an immunomodulatory protein. The recombinant viral construct is hence useful as a bio-tool for simultaneously producing multiple antigens of a bi-subunit vaccine.

Recombinant baculovirus vector and uses thereof

Disclosed herein is anmultiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprisesmultiple nucleopolyhedrovirus (MaviMNPV) genes of lef1, orf1629, pk1, CDS1, CDS2, and lef2; and AcMNPV/MaviMNPV-hybrid genes of egt and orf152. The AcMNPV based hybrid baculovirus is therefore useful as a bio-insecticide by its capability of delivering genes of toxic proteins to be expressed in at least two different insect hosts.

Hybrid baculovirus and uses thereof

Disclosed herein is anmultiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprisesnuclear polyhedrosis virus (BmNPV) genes of lef9, vlf1, p6.9, and vp80;multiple nucleopolyhedrovirus (MaviMNPV) genes of lef2, orf1629, and pe38; and AcMNPV/BmNPV/MaviMNPV-hybrid genes of pk1, lef8, DNA pol, GP41, helicase, orf94, VP1054, orf65, lef4, lef5, and orf99. The AcMNPV based hybrid baculovirus is therefore useful as a bio-tool or bio-insecticide for its capability of delivering genes for production or expression of toxic proteins in at least three different insect hosts.

Hybrid baculovirus having the capability of infecting at least three insect hosts and uses thereof

The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.

Use of biocistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation

Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation

Growing community of inventors

Pingtung County, Taiwan

Ying-Ju Chen