United States Surgical Corporation

Ying Jiang

Mark S Roby

Steven L Bennett

Elliott A Gruskin

Kevin M Connolly

Richard P Stevenson

Cheng-Kung Liu

Jeffrey P Pietrangeli

John S Bobo

Walter Skalla

Nagabhushanam Totakura

Jon T Reinprecht

Lyudmila K Kokish

Kevin Connolly

Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with diketene acetals, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

Bioabsorbable branched polymers end-capped with diketene acetals

Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom

A synthetic absorbable monofilament comprising glycolide and epsilon caprolactone is provided. The monofilament exhibits physical characteristics equivalent to or superior than gut sutures. The monofilaments can be fabricated into a wide variety of surgical devices such as sutures, meshes, and the like.

Absorbable copolymers and surgical articles fabricated therefrom

Block copolymers wherein the first block contains from about 20 to about 80 mole percent of repeating units derived from lactide randomly combined with from about 20 to 80 mole percent of repeating units derived from glycolide and the second block contains repeating units derived from lactide and repeating units derived from other bioabsorbable monomeric units, such as glycolide, the second block containing a higher proportion of repeating units derived from lactide than the first block, with units derived from lactide constituting from about 40 to about 90 mole percent of the entire block copolymer are useful in forming surgical articles, including sutures.

Absorbable block copolymers and surgical articles fabricated therefrom

Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be encapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

Bioabsorbable branched polymer containing units derived from dioxanone and medical/surgical devices manufactured therefrom

A bioabsorbable blend is provided which comprises the reaction product of 1) a bioabsorbable copolymer obtained by polymerizing a major amount of epsilon-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of a polyhydric alcohol initiator and 2) the reaction product obtained by mixing polyalkylene glycol and a coplymer of glycolide/lactide copolymer. The blend has many uses, including that of a coating for a surgical suture.

Bioabsorbable blends and coating composition containing same

Chitosan/alginate post-surgical anti-adhesion barriers, methods of preventing post-surgical adhesions, and methods and devices for forming post-surgical anti-adhesion barriers are provided. An aqueous solution of chitosan and a complexing agent, and an aqueous solution of alginate are combined to form an anti-adhesion barrier at a site of surgical intervention. A medicinal agent may optionally be incorporated.

Chitosan/alginate anti-adhesion barrier

Block copolymers wherein the first block contains from about 40 to about 65 mole percent of repeating units derived from glycolide randomly combined with from about 60 to 35 mole percent of repeating units derived from lactide and the second block contains repeating units derived from glycolide and repeating units derived from lactide, the second block containing a higher proportion of repeating units derived from glycolide than the first block, with units derived from glycolide constituting from about 75 to about 95 mole percent of the entire block copolymer are useful in forming surgical articles, including sutures.

Composite materials have a core portion formed from a biocompatible material and at least one shell portion of a biocompatible material joined to the core portion. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The composite materials may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.

Composite bioabsorbable materials and surgical articles made therefrom

A gut suture is coated with a bioabsorbable copolymer obtained by polymerizing a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of polyhydric alcohol as initiator. The coated gut suture can be packaged in the absence of conventional tubing fluid, i.e., in the dry state, while at the same time retaining flexibility, pliability and resistance to fray. In an alternative embodiment, a gut suture is coated with a pre-coating composition prior to being coated with the bioabsorbable copolymer.

Coated gut suture

Degradable polyesteramide suitable for use in biomedical applications is obtained by reacting diamino alkyl ester with alpha hydroxy acid to form diamide-diol which is reacted with acyl halide or dicarboxylic acid to yield polyesteramide. ##STR1##

Polyesteramide, its preparation and surgical devices fabricated therefrom

Polyesteramides having amino acid-derived groups alternating with hydroxy acid-derived groups are useful in making shaped articles, particularly, shaped articles suitable for use as surgical devices.

Polyesteramides with amino acid-derived groups alternating with

A polyesteramide suitable for use in the fabrication of absorbable surgical devices such as monofilament and multifilament sutures, films, sheets, plates, clips, staples, pins, screws, and the like, is obtained by reacting a monoalkanolamine such as ethanolamine with a diacid halide such as succinic acidchloride to provide a diamidediol and thereafter reacting the diamidediol with the same or different diacid halide under polymerization conditions to form the polyesteramide.

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North Haven, CT, United States of America

Ying Jiang