Industrial Technology Research Institute

Ying-Chih Pu

Chih-Tsung Shih

Chang-Sheng Chu

Chung-Fan Chiou

Ming-Chia Li

Yu-Tang Li

Rung-Ywan Tsai

Shuang-Chao Chung

Jung-Po Chen

Chao-Chi Pan

Hung-Chi Chien

Chein-Shiu Kuo

Guang-Way Jang

Chang-Ming Wong

Yin-Ju Yang

Chih-Fen Chang

Chih-tsung Shih

An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.

Apparatus for single-molecule detection

Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.

Single molecule detection system and methods

Single-molecule detection system and methods

An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.

Method of manufacturing gradient composite material comprises steps of providing plural surface modified inorganic nanoparticles with functional groups or oligomers with functional groups; transferring the surface modified inorganic nanoparticles or oligomers with functional groups into an organic matrix to form a mixture; performing a photo polymerization step or a thermo-polymerization step for polymerizing and generating a gradient distribution of the surface modified inorganic nanoparticles or oligomers with functional groups in the mixture; and curing the mixture to solidify the organic matrix and form a structure with gradient composite, wherein the organic matrix is transferred into an organic polymer after curing.

Gradient composite material and method of manufacturing the same

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Tainan, Taiwan

Ying-Chih Pu