Bened Biomedical Co., Ltd.

Asian Probiotics and Prebiotics Corporation

National Yang Ming Chiao Tung University

National Science Council

Yangsen Biotechnology Co., Ltd.

Hedonist Biochemical Technologies Co., Ltd.

Ying-Chieh Tsai

Chien-Chen Wu

Chih-Chieh Hsu

Jian-Fu Liao

Min-Chang Huang

Hui-Yu Huang

Jyh-Shing Hsu

Yu-Han Chen

Wei-Hsien Liu

Kuo-Wei Tseng

Shuen-Fuh Lin

Jay Hua

Mintze Liong

Chun-Ying Lin

Sawibah Yahya

Sybing Choi

Yen-Wenn Liu

Jiasin Ong

Matthew Cheeyuen Gan

Tan-Wei Liao

Waiyee Low

Yi-Shan Lee

Yi-Chen Juan

Cheng-Sheng Hsu

Szu-Hui Wu

Chia-Li Wei

Yuan-Chi Su

Shu-Ting You

Yun-Fang Cheng

Meng-Hwan Lee

Chin-Lin Huang

Lih-Chiann Wang

Provided are compositions and methods for identifying a specific strain of, e.g.,subsp.PS128 deposited under DSMZ Accession No. DSM 28632.

Oligonucleotides for detectingand method for detectingby using same

An isolated and purified lactic acid bacteria is provided, which isPS23 (PS23) and its applications in delaying aging process, improving immunomodulatory activity, reducing, preventing or treating allergic and inflammation, preventing or treating a chronic disorder and/or (vi) preventing and/or treating a mood disorder or a neurological condition.

Lactic acid bacteria and its applications

This disclosure provides a method of protecting a subject for exercise that prevents an exercise-related harmful effect and reducing exercise fatigue in the subject to thereby enhance physical performance and promote anti-fatigue and anti-inflammatory effects in the subject.

Method for protecting a subject for exercise

The invention relates to a lactic acid bacterium (LAB),PS150, and a bioactive protein produced by the LAB, which has an advantageous effect in improving mood disorder, enhancing cognitive functions in brain and treating or preventing a neurodegenerative disease.

The invention surprisingly found thatsubsp.PS128 provides an advantageous effect in treatment or prevention of tic disorders and basal ganglia disorders. Accordingly, the invention provides a method of treating or preventing a movement disorder in a subject, comprising administering to a subject an effective amount of cells of asubsp.PS128, which is deposited under DSMZ Accession No. DSM 28632.

Method for preventing or treating movement disorders with lactic acid bacterium

The present invention provides an isolated lactic acid bacterium,subsp.PS128 deposited under DSMZ Accession No. DSM 28632, for prophylaxis or treatment of a stress-induced disorder. The present invention further provides a composition for prophylaxis or treatment of a stress-induced disorder that comprisessubsp.PS128. Moreover, the present invention provides a method for prophylaxis or treatment of a stress-induced disorder in a subject that comprises a step of administering an effective amount ofsubsp.PS128 to the subject.

Lactic acid bacterium for prophylaxis or treatment of a stress-induced disorder and a composition containing the same

The present invention provides a method for preventing or treating a functional gastrointestinal disorder in a subject in need thereof that includes a step of administering a composition, wherein the composition includes an effective amount ofsubsp.PS128 and a carrier. The present invention further provides a method for preventing or treating visceral hypersensitivity in a subject in need thereof that includes a step of administering a composition, wherein the composition includes an effective amount ofsubsp.PS128 and a carrier. Moreover, the present invention provides a method for preventing or treating functional abdominal pain, irritable bowel syndrome or constipation in a subject in need thereof that includes a step of administering a composition, wherein the composition includes an effective amount ofsubsp.PS128 and a carrier.

Method for preventing or treating functional gastrointestinal disorder by lactic acid bacterium

The present invention provides an isolated lactic acid bacterium,subsp.K37 strain, deposited in DSME-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GmbH under Accession No. DSM 27445. The present invention further provides a pharmaceutical composition comprising the isolated lactic acid bacterium (subsp.K37). Moreover, the present invention provides a method for preventing or treating a disorder in a subject, comprising a step of administering an effective amount of the isolated lactic acid bacterium (subsp.K37) to the subject.

Lactic acid bacterium having immunomodulatory and anti-allergic effects and pharmaceutical composition containing the same

The invention provides a new lactic acid bacteria (LAB) strain with immunomodulatory and anti-inflammatory activity and a composition containing and method using the same. The LAB of the invention can be administrated for modulating an immune response in order to restore or prevent metabolic disorders caused by obesity or chronic inflammation.

Lactic acid bacteria and its applications in immunomodulation and anti-inflammation

A method for treating/relief of women's menstruation pain. The pain is reduced or relieved by externally administering an effective amount of an essential oil obtained from anthopogon.

Compositions and methods for uterine relaxing

The present invention discloses the use of bismuth subgallate in the inhibition of the production of nitric acid synthase. Also disclosed is the synergistic efficacy of bismuth subgallate in combination with borneol in the inhibition of the production of nitric acid synthase.

Use of bismuth subgallate in inhibition of production of nitric oxide synthase

The method to produce itaconic acid is a solid-state fermentation method. Sugarcane pressmud or peeled sugarcane pressmud is the support used to adsorb liquid medium for the production of itaconic acid by an,mutant strain. This mutant strain was derived from,ATCC 10020 by successive mutation. Beside the remaining sucrose in the sugarcane pressmud, other carbon source can be added, i.e. glucose, fructose, sucrose, or starch hydrolysate. Appropriate amounts of nitrogen source, such as ammonium nitrate, or ammonium sulfate are added. Mineral salts, such as potassium dihydrogen phosphate, magnesium sulfate, calcium sulfate, ferric chloride, zinc sulfate, and copper sulfate can be added to the medium. The suitable amount of liquid medium that can be added to the support is 4 to 6 times its dry weight for the sugarcane pressmud and 8 to 14 times its dry weight for the peeled sugarcane pressmud. The optimal pH of the medium is between 2.0-3.0. The fermentation temperature is between 30-40 degrees centigrade.

Method for the production of itaconic acid using aspergillus terreus solid state fermentation

The invention provides a group of subtilisin YaB mutants, which are obtained by the substitution of the glycine residues at the 124, 151 and 159 positions of wild type subtilisin YaB with other amino acid residues by site directed mutagenesis. The subtilisin YaB mutants have special substrate specificity and relatively higher elastin/casein hydrolyzing activity. The subtilisin YaB mutants can be used in various aspects such as the quality improvement of meat and the protein processing for foodstuff and feedstuff. Moreover, the invention also includes the nucleic acid sequences encoding such enzyme mutants and the uses of such enzyme mutants.

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Taipei, Taiwan

Ying-Chieh Tsai