Shanghai Kechow Pharma, Inc

The Procter Gamble Company

Ying Cheng

Hongqi Tian

Li Kong

Gongchao Huang

Conghui Ji

Chunlei Liu

Li Long Chen

Jiang Yue

Tao Xu

Yueying Wang

Zhimei Zhu

Long Zhu

Andrew Damian Weller

Qianru Zhang

Ying Wang

Li Chen

Andrew Weller

The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A, A, R, R, R, R, and Rand Rare defined herein. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage. 

Amino mercaptan compound and preparation method therefor and use thereof in protection against radiation

Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R, R, R, R, R, R, X, and Xis as defined in the description. These compounds are protein kinases inhibitors, especially the inhibitors of Mek, which are useful in the treatment of cancers and inflammation of mammals. Disclosed are the treatment methods of cancers and inflammation of mammals as well as pharmaceutical expositions comprising the compounds described herein. The preparation of benzoheterocyclic compounds are disclosed. Disclosed are the preparation of potential drug candidates, such as benzooxazol, benzothiazol, benzothiadiazol and the like. 

Benzoheterocyclic compounds and use thereof

Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R, R, R, R, R, R, Xand Xis as defined in the description. These compounds are protein kinases inhibitors, especially the inhibitors of Mek, which are useful in the treatment of cancers and inflammation of mammals. Disclosed are the treatment methods of cancers and inflammation of mammals as well as pharmaceutical compositions comprising the compounds described herein. The preparation of benzoheterocyclic compounds are disclosed. Disclosed are the preparation of potential drug candidates, such as benzooxazol, benzothiazol, benzothiadiazol and the like. 

Disclosed are dentifrice compositions comprising in a single phase: (a) from about 0.1% to about 30% of one or more linear polyphosphates having an average chain length of about 4 or more; (b) an ionic active ingredient selected from the group consisting of a fluoride ion source, a stannous ion source, a zinc ion source, a copper ion source and mixtures thereof, wherein the ionic active ingredient is present as a solid dispersion in the composition and delivers and effective amount of ionic active when solubilized; (c) a binder system comprised of (i) from about 0.05% to about 3% of a thickening agent selected from the group consisting of polysaccharides, carbomers, poloxamers, modified celluloses, and mixtures thereof; and (ii) from about 0.1% to about 70% of at least one humectant; wherein the dentifrice composition has a total water content of less than about 10%. Further disclosed are methods for stabilizing dentifrice compositions by providing such a binder system.

Dentifrice compositions comprising a stable low water, phase comprising polyphosphate and ionic active ingredients

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Tianjin, China

Ying Cheng