Amgen Inc.

Alexion Pharmaceuticals, Inc.

Eli Lilly and Company

Portola Pharmaceuticals, Inc.

Ying Chen

Anjali Pandey

Sheng Cui

Krishnakumar Ranganathan

Richard Crockett

Kevin Crossley

Julian Scott Northen

Sami Karaborni

Arvinder Sran

Liang Huang

Sian Jones

Philippe Fernandes

Yuelie Lu

Gus Kodersha

Daniele Poggiali

Tiziano Fumagalli

Jeroen Bezemer

Asher Lower

John M Schaus

Thomas Daniel Aicher

David Edward Tupper

Vincent Patrick Rocco

Joseph H Krushinski, Jr

Margaret Mary Faul

Dennis C Thompson

Yvan Le Huerou

Zhaogen Chen

Marta Maria Pineiro-Nunez

Pengzu Zhou

Bo Shen

John S Ng

Kevin Michael Ruley

Carlos Orihuela

Xin Wang

Ruizhi Ji

Aleksander Swietlow

Yun Shi

Karel Decroos

Etienne Moniotte

Qi Yan

Forms of cerdulatinib and salts or co-crystals thereof were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the forms cerdulatinib and salts or co-crystals thereof.

Solid forms of Cerdulatinib

A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

Method for preparing AMG 416 (etelcalcetide)

The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I: or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof.

Synthesis of cerdulatinib

Solid forms of cerdulatinib

The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.

Solution phase method for preparing etelcalcetide

A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).

Method for preparing AMG 416

The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.

Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis

Described herein are antipyschotic compounds of formula (I) wherein,

Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders

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Thousand Oaks, CA, United States of America

Ying Chen