Chinese Academy of Sciences

Shanghai Haihe Pharmaceutical Co., Ltd.

Jinan University

Haihe Biopharma Co., Ltd.

Yinchun Ji

Meiyu Geng

Xia Peng

Jingkang Shen

Jing Ai

Bing Xiong

Danqi Chen

Jian Ding

Xin Wang

Jia Tao Li

Qi Rong Wang

Ke Ding

Zhengchao Tu

Tao Meng

Lanping Ma

Xiaomei Ren

Xiaoyun Lu

Li Tan

Zhang Zhang

Yi Zang

Yang Dai

Qian Tan

Hefeng Zhang

Ying Dong

Yuelei Chen

Yuchi Ma

Jing Al

Shingpan Chan

A compound having Axl and c-Met kinase inhibitory activity, a preparation method therefor and an application thereof are provided. Specifically, provided herein are a compound having the structure represented by formula (I), a preparation method therefor and an application thereof in the preparation of a medication for the treatment and/or prevention of tumor-associated diseases and/or kinase-related diseases.

Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof

The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof. 

Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof

This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase. 

Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof

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Shanghai, China

Yinchun Ji