Institute of Molecular & Cell Biology

Yin Hwee Tan

Yue Wang

John S Driscoll

Haishan Wang

Catherine Jane Pallen

Sim Mui Mui

Kah Leong Lim

Su Ling Yeo

Wanjin Hong

Use of a compound of formula (I): wherein 

Protein tyrosine phosphatase inhibitor

Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2'-fluoro-1,1&#x2032;-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synergistic effect can be obtained if an interferon such as interferon &#x3b1;2, interferon &#x3b1;8 or interferon &#x3b2;, or an inhibitor of a second enzyme selected from inosine monophosphate dehydrogenase, guanosine monophosphate synthetase, cytidine triphosphate synthetase and S-adenosylhomocysteine hydrolase, is also administered.

Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases

Proteins such as human &bgr;-interferon or human erythropoietin are prepared by culturing mammalian cells which harbour a nucleic acid sequence comprising: (i) a coding sequence which encodes the desired protein and which is operably linked to a promoter capable of directing expression of the coding sequence in a mammalian cell in the presence of a heavy metal ion; and (ii) a first selectable marker sequence comprises a metallothionein gene and which is operably linked to a promoter capable of directing expression of the metallothionein gene in a mammalian cell in the presence of a heavy metal ion; and optionally (iii) a second selectable marker sequence which comprises a neo gene and which is operably linked to a promoter capable of directing expression of the neo gene in a mammalian cell.

Gene expression in mammalian cells

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Singapore, Singapore

Yin Hwee Tan