University of Shanghai for Science and Technology

Shanghai Neusoft Medical Technology Co., Ltd.

Other

Shenyang Neusoft Medical Systems Co., Ltd.

Chongqing Institute Forfood and Drug Control

Yiming Zhu

Yan Peng

Songlin Zhuang

Chenjun Shi

Yang Liu

Li Zhou

Jun Yu

Shuangxue Li

Zhijia Liu

Lin Guo

Xu Wu

Binbin Qi

Liping Wang

Qingrou Yang

Jiayu Zhao

Xitian Hu

Can Sun

Bowei Xu

Tengfei Zhang

Wanqing Chen

Xinyu Tang

Keying Liu

Songyan Hu

Weinan Ge

Wei Zhang

Jinbiao Zhang

Linggao Zeng

Yujian Yang

Zhengji Ni

Tianyi Kou

Zefang Wang

Zhaozhao Sun

Haicheng Xiao

Xiuping Zhang

Ruijie Peng

Yanchen Zhou

A method for qualitative identification and quantitative determination of caffeine in a drug. In the method, terahertz absorption coefficient spectra of drugs with different concentrations of caffeine are measured, from which the frequency points, amplitudes and peak areas of characteristic peaks of the drugs with different concentrations of caffeine are obtained as characteristic quantities. Concentration gradients are established between the concentrations and the characteristic quantities, respectively. The characteristic quantities are imported to the SVR model to establish a training set and a test set. Finally, the qualitative identification and quantitative analysis of caffeine in unknown drugs are achieved.

Method for qualitative identification and quantitative determination of caffeine in drug

The present disclosure provides a terahertz biological detection method and a device comprising the same, in which biological samples with different molecular formulas have their characteristic peaks in the terahertz band. In the process of sweeping frequency with terahertz, when the terahertz frequency point corresponds to the characteristic peak frequency of the substance to be detected, resonant absorption occurs, and the transmitted/reflected terahertz wave electric field intensity will suddenly decrease. In the electromagnetically induced transparency spectrum corresponding to the Rydberg quantum state, the signal splitting amplitude is significantly reduced. Therefore, the characteristic peak frequency and specific content of the substance to be detected can be accurately determined by comparing the dependence of the Rydberg quantum state with the additional terahertz electric field intensity on the excitation energy level.

Terahertz biological detection method based on five-level rydberg quantum state and device comprising same

Provided is a method for identifying authenticity and origin ofbased on terahertz spectroscopy. The time domain spectral information of thesample is obtained, and converted into the frequency domain spectral information by Fourier transform to calculate a terahertz absorption spectrum. The identification is performed by observing whether there are characteristic absorption peaks of pseudoginsenoside F11 in the terahertz absorption spectrum.

Method for identifying authenticity and origin ofbased on terahertz spectroscopy

Disclosed is a method for qualitative and quantitative determination of key substances in mixture based on terahertz spectrum. Terahertz spectrum of a reference mixture is trained through an SVR algorithm, and predicting parameters of key substances in the mixture to be determined after a model is generated. According to the method, an initial pure spectrum corresponding to each composition in the mixture does not need to be separately determined, no limitation on the number of samples contained in the mixture, and no limitation on frequency range to be determined, and the proportion requirement of the mixture in the early test stage is not limited, and the SVR model does not need to be re-trained after a database is formed in the later stage, and the result can be obtained immediately after the spectrum of item to be determined is introduced into the algorithm model.

Method for qualitative and quantitative determination of key substances in mixture based on terahertz spectrum

The present invention provides a method for detecting petroleum with a staggered toroidal chip, comprising the following steps: step 1, dry the test environment of a terahertz spectrum analysis system, measure a spectrum under dry conditions, and use the spectrum as a reference spectrum; step 2, use a pipette to transfer a crude oil sample and evenly smear it on the metasurface of a staggered toroidal chip; step 3, put the staggered toroidal chip coated with the crude oil sample into the dried terahertz spectrum analysis system, let a terahertz pulse signal of the terahertz spectrum analysis system to be vertically irradiated on the chip for detection, and then get a detection spectrum of the crude oil sample; step 4, subtract the reference spectrum from the detection spectrum, and then get a transmission spectrum of the crude oil sample, wherein the staggered toroidal chip is a terahertz chip designed based on the dual-torus toroidal effect.

Method for detecting petroleum with a staggered toroidal chip

Devices and methods of testing leaking rays are provided. In one aspect, a device includes a first rotary arm configured to rotate around a first rotary axis, a second rotary arm rotatably connected with the first rotary arm and configured to rotate around a second rotary axis, a probe mounted on a rotating end of the second rotary arm and configured to measure a numerical value of leaking rays at each position at which the probe stays, a mounting base rotatably connected with the second rotary arm and configured to mount a ray source component, a first driving unit configured to drive the first rotary arm to rotate around the first rotary axis, and a second driving unit configured to drive the second rotary arm to rotate around the second rotary axis, the first rotary axis being perpendicular to the second rotary axis.

Testing leaking rays

A method for quantitative detection of blood lipid in blood based on terahertz spectroscopy, including: matching the terahertz spectral absorption coefficient curves of blood samples obtained in step 3 with parameters of component concentration and component type of the blood lipid detected by hospital instruments, and establishing a terahertz blood lipid parameter database by combining the time-domain signal data of samples of the triglyceride and cholesterol; determining parameters of a support vector regression (SVR) model; performing a training with the training set as input to the SVR model to obtain a support vector and a corresponding weight; and testing the test set of an unknown blood sample using the trained support vector and the corresponding weight.

Method for quantitative detection of blood lipid content in blood based on terahertz spectroscopy

A method for detecting notoginseng using terahertz technology. The notoginseng samples are pulverized in pulverizer. The pulverized samples are mixed with polyethylene powder in the ratio of 1:4 to 1:6. The powder mixture is pressed in a tablet press to obtain notoginseng tablet. Terahertz spectrograph is started. A peak is saved, and a background signal is measured. The time-domain graph of the background without sample is acquired. The time-domain graphs of the notoginseng tablets are acquired. The time-domain graphs are transformed into frequency-domain graphs by Fourier transform. The frequency-domain graphs are converted to obtain absorption spectrum of the notoginseng tablets. The absorption peak position of test tablet is compared with that of standard tablet to determine its authenticity. The concentration of key active substances of the notoginseng test sample is quantitatively analyzed by integrating the area under absorption peak curve of the notoginseng test sample.

Method for detecting notoginseng using terahertz technology

A device and method of enhancing terahertz wave signals based on a hollow metal waveguide are disclosed. Simple devices such as a beam splitter, multiple plane mirrors, a beam combiner and an adjustable delay system are used. Two laser beams having a wavelength of 800 nm split by the beam splitter generate a fixed time phase delay, and are converged in the hollow metal waveguide to sequentially overlap with pulse of a laser having a wavelength of 400 nm for nonlinear interaction to ionize gas in the optical fiber to generate terahertz waves. The hollow metal waveguide can converge and transmit the generated terahertz waves due to its total reflection characteristics.

Method and device of enhancing terahertz wave signals based on hollow metal waveguide optical fiber

Disclosed is a method of enhancing absorption spectral signals of a biological sample in a terahertz waveband in which the biological sample are embedded and supported with black silicon. In the method, the biological sample are filled between the surface micro-nano structures of a black silicon material and then freeze-dried. When the terahertz wave is incident upon the black silicon material, multiple reflections will occur between the micro-nano structures, so that the terahertz wave passes through the biological sample multiple times to increase the distance of interaction between the terahertz waves and the biological sample, allowing for enhanced absorption spectral signals of the biological sample and improved identifiability of the biological sample. The method is simple and easy to implement and low in cost.

Method of enhancing absorption spectral signals of biological samples in terahertz wavebands

An X-ray collimator used in a CT system is provided, including: a first guide rail and a second guide rail disposed in parallel with each other; and a first gate assembling unit and a second gate assembling unit disposed in parallel with each other. The first gate assembling unit has one end provided with a driving mechanism and fixedly connected with the first guide rail, and another end connected with the second guide rail in a slidable connection. The second gate assembling unit has one end provided with a driving mechanism and fixedly connected with the second guide rail, and another end connected with the first guide rail in a slidable connection. And blocks for supporting and position limiting are provided on two ends of the first guide rail and two ends of the second guide rail. Sheltering effect on X-rays may be improved.

X-ray collimator for CT system

Growing community of inventors

Shanghai, China

Yiming Zhu