Chinese Academy of Sciences

Shanghai Jiaotong University

Shanghai Lead Discovery Pharmaceuticals Limited Company

Yiming Yang

Jing Lan Chen

Jian Li

Hong Tao Liu

Hualiang Jiang

Fei Ye

Kaixian Chen

Jingkang Shen

Jun Zhao

Tao Sun

Jianping Zuo

Quan Yu

Jianhua Shen

Ning Zhao

Bing Xiong

Xu Shen

Xiaomin Luo

Lili Chen

Haibin Luo

Donglu Bai

Fang Ji

Xiaogang Pan

Guohua Tang

Fengting Chu

Chenjie Yang

Chunshan Gui

Qiping Feng

Yifu Yang

Xianhan Zhuang

Xuchang He

Qingling You

Bing Fang

Wenxuan Shi

Lunguo Xia

Lingjun Yuan

Peijun Lu

Zheng Hu

Rongjing Chen

Disclosed is a force applying device for orthodontic treatment being elastically expandable and configured to generate a restoring force as an orthodontic force for an orthodontic treatment when compressed. The force applying device comprises a first element and a second element capable of moving relative to each other along a first axis. The force applying device for orthodontic treatment is compressed when the first and second elements move towards each other along the first axis. A first arm extends laterally from a first end of the first element away from the second element. A first connecting part of a first connector is fitted over the first arm. A second connecting part of the first connector is to be fitted over a button fixed on a first jaw to connect the first element to the first jaw. Both the first and the second connecting parts are toroidal in shape.

Force applying device for orthodontic treatment

The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.

3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs

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Shanghai, China

Yiming Yang