Xi'an Zhongxing New Software Co., Ltd.

Shenzhen Neocura Biotechnology Corporation

Zte Corporation

Yiming Shen

Jian Wang

Yi Tong Wang

Qi Song

Ji Wan

Youdong Pan

A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.

Method and system for calculating tumor neoantigen burden

Provided are a method and a device for determining and sending a priority of a packet, and a routing system. The method comprises: receiving an ARP packet; determining the white list protection entry of the ARP packet according to the dynamic routing protocol subscription information. By means of the present disclosure, the technical problem in the related art that the ARP packet cannot be interacted normally due to an ARP attack is solved.

Method and device for determining and sending priority of packet, and routing system

Growing community of inventors

Shenzhen, China

Yiming Shen