Changzhou No. 4 Pharmaceutical Factory Co., Ltd

Utopharm (shanghai) Co., Ltd

Yimin Yan

Yongrui Tu

Junzhi Luo

Zhaojun Wang

Yongqiang Sun

Mingxia Qian

Xun Luo

A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV is conductive to reacting with methyl lithium or methyl Grignard reagent, a protective group is easy to be removed after a reaction, side reactions are few, a mid-term treatment is simple, the reagents used are cheap, costs are low and a yield is high, if a compound in a constitutional formula V is obtained by the reaction of a compound in a constitutional formula III and the intermediate in the constitutional formula IV, the yield of a two-step reaction is 75%, a purity is above 98%. wherein R is defined in the specification.

Method for preparing ulipristal acetate and key intermediate thereof

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Jiangsu, China

Yimin Yan