Hoffmann-la Roche Inc.

Glaxo Group Limited

F. Hoffmann-la Roche Ag

Yimin Hu

Hong Shen

Xianfeng Lin

Roger David Norcross

Wei Zhu

Guido Galley

Philippe Pflieger

Jian Wang

Zhiwei Zhang

Mingwei Zhou

Taishan Hu

Lei Guo

Guolong Wu

Buelent Kocer

Giuseppe Cecere

Haixia Liu

Houguang Shi

Zhisen Zhang

Buyu Kou

Shixiang Yan

Alexander Mayweg

Lisha Wang

Zehong Wan

Xuefei Tan

Fabian Dey

Weixing Zhang

Xiao Ding

Gangqin Li

Cheng Peng

Xiaomin Zhang

Guozhi Tang

Chengang Zhou

Yun Jin

Zongxing Qiu

Yongqiang Liu

Maarten Vercruysse

Alexander V Mayweg

Roger Norcross

The present invention relates to novel compounds of formula (I), 

Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection

The present invention relates to compounds of formula of formula I wherein X, R, L, Ar, Rand n are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I. 

Morpholin-pyridine derivatives

The present invention relates to compounds of formula of formula I wherein X, L and Rare as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula I. 

2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives

The invention provides novel compounds having the general formula: wherein R, R, Rand Rare as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.

6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The present invention relates to compounds of formula of formula I wherein X, Ar, R, m and n are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I. 

5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives

The invention provides novel compounds having the general formula: wherein R, R, R, Rand A are as described herein, compositions including the compounds and methods of using the compounds.

6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The present invention relates to novel compounds that inhibit Lp-PLAactivity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.

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Shanghai, China

Yimin Hu