Valeant Pharmaceuticals North America

Ribapharm Inc.

Yili Ding

Zhi Hong

Haoyun An

Stephanie Shaw

Nanhua Hugh Yao

Todd Appleby

Shahul Nilar

Various 2'-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particularly useful as therapeutic agents, and especially as antiviral agents.

2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents

A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.

Inhibitors for de novo-RNA polymerases and methods of identifying targets for same

Growing community of inventors

Fountain Valley, CA, United States of America

Yili Ding