Guangzhou Cellprotek Pharmaceutical Co., Ltd

Sun Yat-senuniversity

Yijun Huang

Guangmei Yan

Wei Yin

Bingzheng Lu

Suizhen Lin

Jingxia Zhang

Wenbo Zhu

Pengxin Qiu

Haiyan Hu

Jiesi Chen

Longxiang Sheng

Danyang Liu

Juncheng Pan

Yang Hu

Zhu Zhu

Disclosed is use of 5α-androst-3β,5,6β-triol or an analogue, a deuterated compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of cerebral small vessel disease in a patient. The cerebral small vessel disease is preferably cerebral microbleed. The cerebral microbleed is spontaneous cerebral microbleed, drug-related cerebral microbleed, or traumatic cerebral microbleed. The present invention demonstrates that these compounds significantly enhance the clearance of extravascular hemoglobin, and thus can be used to treat cerebral small vessel disease.

Use of compound in preparation of drug for treating cerebral small vessel disease

Methods for treatment of a multi-drug resistant (MDR) tumor in a subject are disclosed. The methods comprise administering to the subject in need of treatment a therapeutically effective amount of an anti-agent and/or an agent blocking the interaction between membrane protein P37 ofand Annexin A2 of host cells of the subject, prior to, at the same time with, or after chemotherapy. Relevant pharmaceutical compositions, kits, uses are also disclosed.

Methods and compositions for treatment of multi-drug resistant tumors

Disclosed is a use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol, an analogue, a deuterated derivative, and a pharmaceutically acceptable salt thereof in manufacture of a medicament for the treatment of hemorrhagic stroke in a patient. The hemorrhagic stroke is intracerebral hemorrhage or subarachnoid hemorrhage.

Use of compounds in preparation of a medicament for treatment of hemorrhagic stroke

Use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol and analogs thereof in the preparation of a drug for the prophylaxis or treatment of an altitude sickness caused by hypobaric hypoxia is provided, so as to provide a new drug for the prophylaxis or treatment of an altitude sickness. Researches revealed that 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol treatment can effectively reduce vasogenic edema of brain tissue ofcaused by hypobaric hypoxia, reduce the increased cerebral water content, and protect from neuronal vacuolar degeneration caused by hypobaric hypoxia, therefore it can improve neurological dysfunctions caused by hypobaric hypoxia and is useful in prophylaxis or treatment of an altitude sickness.

Neuro-protective agents and uses thereof

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Guangdong, China

Yijun Huang