Shenzhen Pregene Biopharma Co. Ltd.

Yijin Ding

Jishuai Zhang

Hongjian Li

ChaoLemeng Bao

Qinghua Cai

Zhibo Cai

Zongpei Song

Chaolemeng Bao

Yingying Li

Hongchang Su

A group of anti-BCMA single domain antibodies, as well as genes of the single domain antibodies in the group, a vector containing the single domain antibodies in the group, a chimeric antigen receptor, and a T cell modified by a chimeric antigen receptor, and detection and treatment application of the single domain antibodies in the group. The anti-BCMA single domain antibodies have high activity, high stability, high specificity, and high binding capability.

Anti-BCMA single domain antibodies and application thereof

A chimeric antigen receptor (CAR) may be include: a BCMA binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain, wherein the BCMA binding domain includes heavy chain complementarity determining regions HCDR1-3, and the amino acid sequences of the HCDR1-3 are successively as shown in SEQ ID NO: 1-3.

BCMA chimeric antigen receptor based on single domain antibody and use thereof

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Shenzhen, China

Yijin Ding