University System of Maryland

University of Utah Research Foundation

Johns Hopkins University

Yihua Bruce Yu

Marc B Taraban

Yue Feng

Yiider Tseng

Zhong-Xing Jiang

Sivakumar Ramachandran

Katharine T Briggs

A method of using the relaxation rate (Rand/or R) of solvent NMR signal to invasively or noninvasively assess whether vaccines and other aqueous-based pharmaceutical products have been frozen during transport and/or storage.

Detection of pharmaceutical product freezing history using water proton NMR

The present invention generally relates to a method of using the transverse relaxation rates (R) of solvent NMR signal to noninvasively assess particle-containing products formulated as suspension or emulsion in solvent(s). Anomaly in released products and differences between innovator and follow-on products can be distinguished by this technology nondestructively without the vial or container being opened or protective seal compromised (i.e., broken).

Solvent nuclear magnetic resonance for noninvasive inspection of particle-containing products

The present invention generally relates to a method of using NMR relaxation rates (R) of water molecules as an indicator of the extent of aggregation of biopharmaceutical formulations. The biopharmaceutical can be evaluated nondestructively without the vial or container being opened or protective seal compromised (i.e., broken). The method is applicable to all biopharmaceuticals and the water signal obtained by magnetic resonance relaxometry is very strong and sensitive because water is used as the solvent and is present in high (&#x3e;90%) concentrations in every biopharmaceutical formulation.

Biopharmaceutical aggregation assessment and counterfeit detection using magnetic resonance relaxometry

Assessing biopharmaceutical aggregation using magnetic resonance relaxometry

The compositions and methods disclosed herein pertain to the manufacture and use of hydrogels. The disclosed compositions and methods pertain to hydrogels capable of induction by a variety of methodologies, such as by pH, salt and/or mixing. Such hydrogels are capable of self- or co-assembly and while doing so, may entrap a variety of bioactive agents in their native form, such as proteins, DNA, RNA and the like. The hydrogels of the present invention also demonstrate rapid sheer-responsiveness. The hydrogels of the present invention are biodegradable, biocompatible and useful as a biomaterial or drug-delivery device.

Electrostatically controlled hydrogels

Techniques include determining, non-invasively and without applying deformational stress, a nuclear magnetic resonance relaxation rate at a volume inside a subject. The method also includes determining a mechanical property of material at the volume inside the subject based on the nuclear magnetic resonance relaxation rate.

Noninvasive characterization of mechanical properties of materials and tissues using magnetic resonance techniques

Disclosed are compounds comprising the structure: In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

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Ellicott City, MD, United States of America

Yihua Bruce Yu