Yeda Research and Develpment & Co. Ltd

Prochon Biotech Ltd.

Yeda Research and Development Company Ltd at Weizmann Institute of

Yigal Burstein

Nathan Trainin

Avner Yayon

Oren Bogin

Moshe Peretz

The present invention discloses the isolation and use of a specific bacterial promoter region suitable for use in constructs for the high level production of heterologous proteins. This promoter is derived from the bacterial gene encoding for alcohol dehydrogenase, in particular the alcohol dehydrogenase genes isolated from the thermophilic bacterial strainand the mesophilic bacterial strain. It is now disclosed that using either the intact promoter region or certain specific fragments consisting of at least a 88 bp DNA sequence in the upstream untranslated region of the bacterial alcohol dehydrogenase gene, operatively linked to the nucleic acid sequences encoding a heterologous protein, and insertion into a DNA plasmid or any other suitable vector system, heterologous genes can be expressed in high levels in host cells. Heterologous proteins or peptides can be expressed constitutively at high levels. The proteins are obtained in their active folded form.

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An immunomodulatory peptide is disclosed which is a thymic humoral factor .gamma.2 (THF-.gamma.2) analog of at least eight amino acids or a functional derivative or a salt thereof. The peptide has the amino acid sequence: Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu (SEQ ID No:1) but differing therefrom by

THF-.gamma.2 analogs and pharmaceutical compositions comprising them

Novel peptide materials having thymic humoral activity are disclosed having the respective amino acid sequences of:

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Rehovot, Israel

Yigal Burstein