Brainsway Ltd.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The Weizmann Institute of Science

Yeda Research and Develpment & Co. Ltd

B.G. Negev Technologies and Applications Ltd.

Elminda Ltd.

The Government of the United States of America

Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

Yiftach Roth

Abraham Zangen

David Hazani

Pedro Cavaleiro Miranda

Mark Hallett

Gaby S Pell

Vadim Chudnovsky

Mark Hallet

Noach Safra

Udi Vazana

Alon Friedman

Roy A Wise

Amir B Geva

Ziv Peremen

Revital Shani-Hershkovich

Uri Alyagon

Dror Haor

Boaz Sadeh

Ronen Segal

Samuel Zibman

Roie Cohen

Gaby Pell

Brain stimulation techniques are disclosed, utilizing a brain state monitoring and stimulating component having at least one processor and memory, and a digital signal processing unit configured and operable to predict at least one brain state about to occur in a brain of a treated subject based on data or signals indicative of at least one brain state of the treated subject. The digital signal processing unit can be configured to generate based on the predicted at least one brain state stimulation data for adjusting, regulating or triggering, brain stimulation signals applied to the brain of the treated subject. The at least one processor, memory, and digital signal processing unit are embedded in some embodiments in a single hardware device.

Device and method for real-time closed-loop brain stimulation

Apparatus and methods are described for use with electrophysiological signal detecting electrodes, and a transcranial magnetic stimulation device. A computer processor drives the transcranial stimulation device to apply one or more pulses of transcranial magnetic stimulation to a subject. Within a given time period of applying one of the one or more pulses of transcranial magnetic stimulation to the subject, the computer processor detects an electrophysiological signal of the subject, using the electrophysiological signal detecting electrodes. At least partially in response thereto, the computer processor predicts an outcome of treating the subject for a neuropsychiatric condition, using a given therapy, and generates an output on an output device in response to the predicted outcome. Other applications are also described.

Apparatus and methods for predicting therapy outcome

Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.

Use of transcranial magnetic stimulation to modulate permeability of the blood-brain barrier

An electromagnetic coil assembly for inducing electromagnetic fields in a head region of a treated subject, the assembly comprising windings configured to define an applicatory coil portion configured for placement in close proximity to the head to induce the electromagnetic fields, and an elevated coil portion passing relatively remote from the head and configured such that electromagnetic fields thereby produced are generated substantially remote from the head, thereby allowing directing the electromagnetic fields generated by the applicatory coil portion substantially accurately to desired inner regions of the head. A support structure is used to enclose and immobilize at least a portion of the windings, while enabling elastic movement of other portions of the windings that are not held by the support structure, to thereby enable size adjustment of the coil to fit over a region of a head of the treated subject.

Electromagnetic coil assembly

A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.

Central base coils for deep transcranial magnetic stimulation

A system and methods for controlling pulse parameters during transcranial magnetic stimulation are provided. Multiple coils are placed on external body parts, and are controlled using an external control unit coupled to a stimulator having fast switches. The timing of the switches, as well as other parameters within the stimulator, determine the pulse parameters, such as pulse shape. The variety of pulse shapes obtainable using such a system and methods provides controlled physiologic effects within an internal body organ.

Systems and methods for controlling electric field pulse parameters using transcranial magnetic stimulation

A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

Transcranial magnetic stimulation system and methods

A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.

Circular coils for deep transcranial magnetic stimulation

A coil for transcranial magnetic stimulation which is location-specific for unilateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements and return elements are distributed on one side of a central axis of the coil.

Unilateral coils for deep transcranial magnetic stimulation

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Rechelim, Israel

Yiftach Roth