Shanghai Institute of Pharmaceutical Industry

China State Institute of Pharmaceutical Industry

Js Innopharm (shanhai) Ltd.

Js Innopharm Ltd.

Yifang Deng

Quanhai Liu

Xiaoling Huang

Ying Liu

Zhen Zhang

Guoping Wang

Minyu Liu

Li Cai

Xuejun Wu

Renhai Chen

Lin Xiao

Jintao Zhang

Jinyao Chen

Guobin Ren

Yan Qin

Haiyan Sun

Zhiru Xu

Chungang Li

Mianli Pan

Shenrong Tang

Pengxia Yu

Liling Jin

Xiangduan Tan

Gouping Wang

Zhenpeng Yu

Tian Zhang

Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R, R, R, R, R, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Amide compound, preparation method and uses thereof

Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereof. 

Heterocyclic compounds for treating psoriasis

An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

Amorphous asiatic tromethamine salt and preparation method thereof

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Shanghai, China

Yifang Deng