3m Innovative Properties Company

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Yifan Zhang

Naiyong Jing

Matthew T Scholz

Yu Yang

Diane R Wolk

Wei Gao

Justin A Riddle

Mitchell Ho

Yen T Phung

Ira H Pastan

Zai-Ming Qiu

Chetan P Jariwala

Caroline M Ylitalo

Mahfuza B Ali

Robin Edgar Wright

Suresh Iyer

Louis C Haddad

Narina Y Stepanova

Liming Song

Richard L Walter

Linda K M Olson

Michael J Svarovsky

Cordell M Hardy

Katherine A Gibney

Jessica M Buchholz

Ingrid N Haugan

Raffit Hassan

Larry R Krepski

William J Schultz

Michael R Berrigan

Douglas Eugene Weiss

Scott J Tuman

Yi He

John D Stelter

Terry R Hobbs

James P Gardner, Jr

Eric M Moore

Lylien Tan

Elaine M Yorkgitis

Francis E Porbeni

Milind Balwant Sabade

Michelle L Legatt

Zachary J Malmberg

Korey W Karls

Sian F Fennessey

Andrew S D'Souza

Mark W Nelson

David D Lu

Stephen Richard Hartshorn

Alexandra L Sevenich

Andrew S D'SOUZA

James P Gardner

Stephen Hartshorn

Modified poly(diorganosiloxanes), compositions, and articles comprising the same. The modified poly(diorganosiloxanes) can be soluble or dispersable in aqueous media. The articles can have modified poly(diorganosiloxanes) affixed thereto.

Compounds comprising modified diorganosiloxane polymers

Compositions include a water-soluble copolymer, a hydrophilic silane compound, and in some embodiments surfactant dispersed in a liquid phase. Methods of using the compositions to coat and optionally clean a substrate are also disclosed.

Composition suitable for protection comprising copolymer and hydrophilic silane

Compositions include a water-soluble polymer, silica nanoparticles, and a combination of a nonionic and anionic dispersed in an aqueous liquid phase. The polymer is a water-soluble copolymer of acrylic acid and an acrylamide, or a salt of the same. Methods of using the compositions to clean and coat a substrate are also disclosed.

Aqueous composition suitable for cleaning and protection comprising silica nanoparticles, copolymer of acrylamide and acrylic acid, nonionic and anionic surfactant

Fluorinated silane compounds, compositions containing the fluorinated silane compounds, and articles prepared using the fluorinated silane compounds and compositions are described. The fluorinated silane compounds can be soluble or dispersible in aqueous media, such as water, and can be used to coat articles, such as glass articles.

Fluorinated silane compounds, compositions, and articles

Fibers, which can be used for making wipes (e.g., antimicrobial wipes), wherein the fibers include a core comprising an aliphatic polyester; and an epoxidized fatty ester having greater than 4.7 wt-% oxirane oxygen, based on the total weight of the epoxidized fatty ester; wherein the epoxidized fatty ester is disposed on the surface of the fiber core.

Fibers and wipes with epoxidized fatty ester disposed thereon, and methods

Fibers, which can be used for making wipes (e.g., antimicrobial wipes), wherein the include: an aliphatic polyester; an unreacted epoxidized fatty ester having greater than 4.7 wt-% oxirane oxygen, based on the total weight of the epoxidized fatty ester; wherein the aliphatic polyester and unreacted epoxidized fatty ester form a mixture.

Fibers, wipes, and methods

A method of removing an unwanted constituent from a siliceous surface in which the method includes contacting the siliceous surface and the unwanted constituent with a multi-functional composition that includes water, a hydrophilic silane, and a surfactant, and drying the surface.

Method of removing an unwanted constituent from a surface, a method of determining the cleanliness of a hard surface, and a multi-functional composition that includes hydrophilic silane

Described herein is the use of rabbit hybridoma technology, along with a panel of truncated mesothelin domain fragments, to identify anti-mesothelin mAbs that bind specific regions of mesothelin. In one aspect of the present disclosure, the rabbit mAbs bind an epitope that is not part of Region I. In particular, the identified mAbs (YP187, YP223, YP218 and YP3) bind either Region II (391-486), Region III (487-581) or a native conformation of mesothelin with subnanomolar affinity. These antibodies do not compete for binding with the mesothelin-specific immunotoxin SS1P or mesothelin-specific antibody MORAb-009. In another aspect, disclosed is a high-affinity rabbit mAb that binds Region I of mesothelin (YP158). YP158 binds native mesothelin protein in cancer cells and tissues with high affinity and specificity.

Mesothelin domain-specific monoclonal antibodies and use thereof

Dimensionally stable nonwoven fibrous webs include a plurality of fibers formed from one or more thermoplastic polyesters and an antishrink additive, preferably in an amount greater than 0% and no more than 10% by weight of the web. The webs have at least one dimension which decreases by no greater than 12% in the plane of the web when heated to a temperature above a glass transition temperature of the fibers. The webs may be used as wipes.

Dimensionally stable nonwoven fibrous webs, and methods of making and using the same

Described herein is the identification of a panel of high affinity monoclonal antibodies that bind GPC3. The disclosed antibodies recognize native GPC3 on the surface of cancer cells, as well as soluble GPC3. The highest affinity antibody (YP7) was further characterized and shown to be highly sensitive in that it was capable of detecting cancer cells with low expression of GPC3. YP7 also exhibited significant HCC tumor growth inhibition in vivo. Immunotoxins comprising the antibodies disclosed herein fused to PE38 exhibited very high binding affinity for GPC3-expressing cells and significantly inhibited GPC3-expressing cancer cell growth. Thus, the high-affinity monoclonal antibodies disclosed herein can be used for the diagnosis and treatment of GPC3-expressing cancers.

High-affinity monoclonal antibodies to glypican-3 and use thereof

Compositions include a polymer and silica nanoparticles dispersed in an aqueous continuous liquid phase. The polymer is a water-soluble copolymer of acrylic acid and an acrylamide, or a salt of the same. Methods of making and using the compositions to coat a substrate are also disclosed.

Aqueous coating composition comprising spherical silica particles and method of making and using the same

Compositions include an aqueous continuous liquid phase and core-shell particles dispersed in the aqueous continuous liquid phase. Each core-shell particle includes a polymer core surrounded by a shell consisting essentially of nonporous spherical silica particles disposed on the polymer core, wherein the nonporous spherical silica particles have a volume average particle diameter of 60 nanometers or less. Methods of making and using the compositions to coat a substrate are also disclosed.

Coating composition and method of making and using the same

Polymeric beads and methods of making the polymeric beads are described. The polymeric beads are crosslinked hydrogels or dried hydrogels. The polymeric beads are formed from droplets of a precursor composition that are exposed to radiation. The droplets are totally surrounded by a gas phase. The precursor composition contains a polar solvent and a polymerizable material miscible in the polar solvent. The polymerizable material has an average number of ethylenically unsaturated groups per monomer molecule equal to at least 1.2.

Polymeric beads and methods of making polymeric beads

Growing community of inventors

Woodbury, MN, United States of America

Yifan Zhang