University of Kansas

Yibai Hu

George S Wilson

Norio Matsumoto

Xiaohong Chen

Improved biosensors are provided having excellent selectivity and stability properties, together with methods of preparing the biosensors. A preferred biosensor includes an electrode ( ) having enzyme ( ) deposited thereon together with a layer of electropolymerized polymer ( ) intermingled with the enzyme ( ); a crosslinked silane film ( ) is applied over the polymer layer ( ), and a final coating ( ) of polyurethane is formed over the film ( ). In preparative procedures, the enzyme ( ) is electrodeposited using an aqueous enzyme solution containing a nonionic surfactant at a concentration level preferably in excess of the critical micelle concentration of the surfactant. In the case of a glucose sensor, the polymer layer ( ) is preferably polyphenol, while the silane film is crosslinked (3-aminopropyl) trimethoxysilane. The preferred biosensors have greatly enhanced selectivity stabilities.

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Lawrence, KS, United States of America

Yibai Hu