Life Technologies Corporation

Other

C Sixty Inc.

Yi-Zhen Hu

Kyle R Gee

Aimei Chen

Xin Wang

Hee Chol Kang

Robert Aggeler

Yexin Wu

Kathleen Free

Daniel Beacham

Eric Welch

Chrisgen Vonnegut

Adam York

Kathleen Kihn

Quentin Low

Krishnamurthy Nacharaju

Stephen R Wilson

Aleksey Rukavishnikov

Jongtae Yang

Bhaskar Mandavilli

Tong Zhu

Russ Lebovitz

The present disclosure provides for compounds of Formula (I), its corresponding compounds of Formula (II) or salts thereof and their use as fluorogenic pH sensors.

Fluorogenic pH-sensitive compounds and their methods of use

Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

Fluorescent particles

Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.

Silicon-substituted rhodamine dyes and dye conjugates

Provided herein are compounds, compositions, kits, uses, and methods for assessing the viability of cells and/or quantifying the amount of live and dead cells in a mixture using differential stains. In some embodiments, the compounds are used in culture media or can function independently of fixation and/or permeabilization. In some embodiments, the compounds comprise a platinum atom. In some embodiments, the compounds comprise a nitrogen mustard moiety.

Methods and compositions for assessing cell viability

Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Dibenzosilole monomers and polymers and methods for their preparation and use

Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.

Large stokes shift dyes

Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.

Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species

This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (&#x3e;CXX) groups bonded to the fullerene core; (ii) from 1 to 18 &#x2014;Xgroups bonded to the fullerene core; (iii) from 1 to 6 &#x2014;X&#x2014; groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.

Substituted fullerene compositions and their use as antioxidants

Growing community of inventors

Eugene, OR, United States of America

Yi-Zhen Hu