Taipei Medical University

National Health Research Institutes

Yi-Yuan Yang

Ko-Jiunn Liu

Sy-Jye Leu

Neng-Yao Shih

I-Jen Huang

Yu-Ching Lee

Yuan-Soon Ho

Wen-Shyang Hsieh

Chi-Hsin Lee

Hsueh-Hsia Wu

Ching-Hua Su

Shih-Lan Hsu

Yun-Liang Yang

Shih-Yi Huang

Suparat Charoenfuprasert

Hsiu-Jung Lo

Yu-Jia Chang

Yueh-Lun Lee

Yung-Luen Shih

Ching-Yu Lin

Mei-Ru Chen

Yung-Leun Shih

Bor-Yu Tsai

The invention provides anti-CaENO1 antibodies and humanized antibodies as effective diagnostic agent or therapeutic treatment against infections caused byspp. (preferably), fluconazole resistancespp.,, or

Antibodies against infectious diseases

Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused byspp., preferably, fluconazole resistancespp.,

The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.

Method for the diagnosis of the presence of an ovarian cancer

The invention relates to antibodies against &#x3b1;-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-&#x3b1;-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-&#x3b1;-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.

Anti-&#x3b1;-enolase I antibodies for diagnosis and treatment of &#x3b1;-enolase I-associated diseases

The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.

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Antigen polypeptide for the diagnosis and/or treatment of ovarian cancer

The present invention provides a method for the treatment and/or prevention of bacterial infection caused byand other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused byfamily in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused byfamily in central nervous system and/or peripheral blood circulation in a mammal.

The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.

Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation

Growing community of inventors

Taipei, Taiwan

Yi-Yuan Yang