Nanjing Canatal Data-centre Environmental Tech. Co., Ltd.

Nanjing Medical University

Affiliated Stomatological Hospital of Nanjing Medical University

Yi Yuan

Lingyun Wang

Weixing Zhang

Zongqin Zhang

Jun Tian

Hongwei Li

Liyong Pu

Heming Wu

Yaqin Zhang

Jindao Wu

Embodiments of the present disclosure provides a method of preparing an adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative, including: activating a carboxyl group of a cysteine residue at the C-terminus of an adipose tissue-targeting polypeptide to form an acyl chloride; reacting a verbascoside with a sodium hydroxide to obtain a sodium phenolate; esterifying the acyl chloride with the sodium phenolate to form an adipose tissue-targeting polypeptide-verbascoside derivative; and reacting the adipose tissue-targeting polypeptide-verbascoside derivative with PEG-modified nanogold particles. The present disclosure further discloses an adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative and the application of the adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative in preparing a drug for the treatment of obesity. The adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative has good biocompatibility, and capable of carrying drugs into the adipocytes, thereby greatly enhancing the availability of the drug and significantly improving the targeted anti-obesity activity of the drug.

Adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative, preparation method and application thereof

A gravity-assisted heat pipe cooling source cold storage system and chiller set. The cold storage system includes a gravity-assisted heat pipe, a cold storage pool, a heat exchanging and cold condensing device, and a heat exchanger pipe. A lower end of the gravity-assisted heat pipe is arranged in the cold storage pool, and an upper end of the gravity-assisted heat pipe is arranged in the heat exchanging and cold condensing device. The heat exchanger pipe is buried underground, and includes a central pipe and a side pipe. Upper ends of the central pipe and the side pipes are communicated with an inlet and outlet of the heat exchanging and cold condensing device, respectively. Lower ends of the central pipe and the side pipes are communicated with each other. The system employs the heat exchanger pipe to provide a cooling source for the gravity-assisted heat pipe.

Gravity-assisted heat pipe cooling source cold storage system and chiller set

A gravity-assisted heat pipe ground cooling source cold storage system and a chiller set. The cold storage system includes a gravity-assisted heat pipe, a cold storage pool, a heat exchanging and cold condensing device, and a heat exchanger pipe. An inlet and outlet of the cold storage pool are parallel-connected to cold water pipes of a chiller set, and are connected or disconnected via control valves. The heat exchanger pipe is buried underground, and includes a flow inlet pipe and a flow return pipe having a cross section including a first arc, a second arc, a third arc, and a fourth arc. The second arc and the fourth arc are S-shaped arcs. The first arc has a radius exceeding that of the third arc, and centers of circles of the first arc and third arc are located at the cross section of the flow return pipe.

Gravity-assisted heat pipe ground cooling source cold storage system and chiller set

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Nanjing, China

Yi Yuan