National Taiwan University

Academia Sinica

Yi-Ying Wu

Pan-Chyr Yang

Tse-Ming Hong

Yuh-Ling Chen

Ang Yuan

Hung-Chih Kuo

The present disclosure provides a method of reducing neurodegeneration and/or TDP43 associated aggregation, comprising knocking down the expression of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) or LncRNA NEAT1. Also provided are methods for screening a candidate agent that reduces neurodegeneration and/or TDP43 associated aggregation in a cell, treating or preventing a neurodegenerative disorder, delaying or preventing the onset of a neurodegenerative disorder or reducing a risk for developing a neurodegenerative disorder in a subject and determining whether a subject is suffering from, or at a risk of developing a neurodegenerative disorder, comprising measuring the presence of cytoplasmic NEAT1 in a biological sample, wherein the presence is indicative of the risk of developing a neurodegenerative disorder.

Nuclear paraspeckle assembly transcript 1 as therapeutic targeting in neurodegeneration

The present invention provides a cyclic peptide containing RRXR motif. The present invention also provides a composition comprising the said cyclic peptide and a pharmaceutical acceptable carrier. The present invention further provides a method for treating cancer.

Composition for treating cancer and use thereof

Growing community of inventors

Taipei, Taiwan

Yi-Ying Wu