Agency for Science, Technology and Research

International Business Machines Corporation

Yi-Yan Yang

Yong Xin Wang

Ashlynn Lingzhi Lee

Zhan Yuin Ong

Wei Liu

Jackie Yi-Ru Ying

Chuan Yang

Kazuki Fukushima

Tai-Shung Chung

Wei Cheng

Charlotte A E Hauser

Kumaresh Soppimath

Nikken Wiradharma

Cherng-wen Tan

Shao-Qiong Liu

Jimmy Kwang

Xueqin Chen

The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.

Polymer for delivery of biologically active materials

Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.

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The present invention relates to antimicrobial peptides, to their use as antimicrobial agents and to their use in the treatment of (infectious) diseases, in particular infectious diseases caused by Gram-positive bacteria, Gram-negative bacteria, yeast or fungi. The present invention further relates to pharmaceutical compositions and kits comprising the antimicrobial peptides and to a method of lysing bacterial, yeast or fungal cells. The antimicrobial peptides consist of one of the following general formula: Wherein X is a hydrophobic amino acid, Y is a cationic amino acid, Z is an amino acid having a free thiol or thioether group, n is 2-4 and m is 0 or 1. 

Antimicrobial peptides

Disclosed is the method of treating keratits in a subject thereof comprising administering into the subject an amphiphilic peptides of the present disclosure. Also disclosed are methods of removing biofilm from cornea.

Amphiphilic peptides for treatment of keratitis

Articles and methods for the delivery of drugs and/or nucleic acids. Articles including a nanoparticle are provided that may be used for the delivery of a drug, a nucleic acid, or both, to a subject. The articles may be of polymeric material and may self-assemble.

Methods and articles for the delivery of therapeutic agents

The invention provides a block copolymer comprising at least a first block and a second block. The first block comprises a plurality of temperature-sensitive monomeric units, a plurality of hydrophilic monomeric units and a plurality of targeting monomeric units, and the second block comprises a plurality of hydrophobic monomeric units. The second block comprises at least one pH-sensitive moiety.

Micelles for drug delivery

There is presently provided a complex of a micelle formed from a cationic polymer and a protein, and a method using the complex to deliver the protein into a cell.

Method of delivering a protein into a cell

The invention is directed to a copolymer comprising at least three types of monomeric units, said three types of monomeric units comprising:

Temperature and pH sensitive copolymers

Biodegradable and biocompatible polymeric microspheres encapsulatingare administered to chickens to provide the chickens with sustained protection againstinfections.

Growing community of inventors

Singapore, Singapore

Yi-Yan Yang