International Business Machines Corporation

Agency for Science, Technology and Research

Institute of Bioengineering and Nanotechnology

Coral Bay Ii, Llc.

National University of Singapore

Agency for Science, Technology

Institute of Bioengineering and Nanotechnology, Biomedical Sciences Institute

Universidad Del Pais Vasco/euskal Herriko Unibersitatea

Universidad Del Par&#xed;s Vasco/euskal Herriko Unibertsitatea

Yi Yan Yang

James L Hedrick

Nathaniel H Park

Chuan Yang

Mareva B Fevre

Victoria A Piunova

Amanda Catherine Engler

Daniel Joseph Coady

Rudy J Wojtecki

Pang Kern Jeremy Tan

Jeannette M Garcia

Xin Ding

Willy Chin

Ashlynn L Z Lee

Victor W L Ng

Robert J Ono

Zhen Chang Liang

Zhi Xiang Voo

Dylan J Boday

Theodore Gerard Van Kessel

Amos Cahan

Kazuki Fukushima

Shrinivas Venkataraman

Julian M W Chan

Ashlynn Lingzhi Lee

Jeremy P K Tan

Mu San Zhang

Xiyu Ke

Jye Yng Teo

Shaoqiong Liu

Alshakim Nelson

Richard Anthony Dipietro

Wei Cheng

Qingxing Xu

Cherylette Anne Alexander

Zhan-Yuin Ong

Hariklia Deligianni

Motoichi Kurisawa

Pei-Yun S Hsueh

Joo Eun Chung

Lang Zhuo

Jiayu Leong

Haritz Sardon

Nor Lizawati Ibrahim

Gregory Breyta

Wei Han

Gavin O Jones

Dmitry Zubarev

Mark Kunitomi

Jed Walter Pitera

James Lupton Hedrick

Simone Bianco

Noah F Fine Nathel

Eddy Wei Ping Tan

Yiran Zhen

Paola Florez De Sessions

Balamurugan Periaswamy

Eunice Leong

Jeremy Tan

Ichiyama Koji

Naoki Yamamoto

Yang Chuan

Pei Yun Teo

Richard Anthony DiPietro

Enara C Vijil

Payel Das

Li Wang

Hareem Tariq Maune

Inkit Padhi

Min-Han Tan

Kahini Wadhawan

Zhan Yuin Ong

Yukti Choudhury

Kumaresh Soppimath

Flaviu Cipcigan

Jeremy Pang Kern Tan

Agnes Mari Kuroki

Wei Ping Eddy Tan

Eunice Leong Jiayu

Shujun Gao

Jeremy Pk Tan

Shao Qiong Liu

Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, 'R' can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.

Post polymerization modification in flow

Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.

Biodegradable functional polycarbonate nanoparticle carries for delivering molecular cargo

A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.

Biocompatible and biodegradable antiviral polymers

Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.

Combination therapies that enhance antimicrobial/anticancer activities

Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.

Antimicrobial guanidinium macromolecules with bacteria targeting moieties

Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.

Star polymers with enhanced antimicrobial activity in response to light

A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.

Stimulus-responsive micellar carrier

Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

Utilizing polymers and antibiotics to enhance antimicrobial activity and inhibit antibiotic resistance

Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

Polylysine polymers with antimicrobial and/or anticancer activity

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.

Polymers with antimicrobial functionalities

Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.

Antimicrobial guanidinium and thiouronium functionalized polymers

Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.

Antimicrobial polymers capable of supramolecular assembly

Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

Prevention of biofilm formation

A method for formation of a vaccine comprising combining a cationic polymer adjuvant with an antigen to form first immunoparticles through charge interactions and producing a treatment formulation for the vaccine comprising the first immunoparticles.

Biodegradable cationic polycarbonates as adjuvants for vaccines

Growing community of inventors

Singapore, Singapore

Yi Yan Yang