Amyris, Inc.

Yi Xiong

Gale Wichmann

Chantal Garcia De Gonzalo

Shaina Jackson

Wenzong Li

Sean Lund

Hailley Warbington

Svetlana Alekseyevna Borisova

Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding akaurenoic acid hydroxylase. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.

kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides

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Emeryville, CA, United States of America

Yi Xiong