Easel Biotechnologies LLC

Yi-Xin Huo

Shahrooz Rabizadeh

Lars Erik Ulf Rohlin

Kwang Myung Cho

Benjamin Schilling

Methods and systems for the production of alcohols are described. A two stage process is utilized, where fermentation in a first stage produces an intermediate product, such as an amino acid or organic acid, from a carbon containing feedstock. A second stage produces alcohol by fermentation of this intermediate product.

Two-stage production of higher alcohols

Genetically engineered cells and methods are presented that allow for the production of various value products from CO. Contemplated cells have a CBB cycle that is genetically modified such that two molecules of COfixed in the CBB cycle can be withdrawn from the modified CBB cycle as a single C2 compound. In contemplated aspects a CBB cycle includes an enzymatic activity that generates the single C2 compound from a compound of the CBB cycle, while further modifications to the CBB cycle will not introduce additional recombinant enzymatic activity/activities outside the already existing catalytic activities in the CBB cycle.

Carbon dioxide fixation via bypassing feedback regulation

Systems, methods, and metabolically engineered microorganisms are contemplated in which low molecular weight gases, and especially methane and syngas are used as a carbon source, and in which COor formaldehyde and reduction equivalents are generated for use in in vivo production of the value products.

Growing community of inventors

Los Angeles, CA, United States of America

Yi-Xin Huo