Novartis Vaccines & Diagnostics, Gmbh

The Wellboss Company, LLC

Novartis Ag

Anacor Pharmaceuticals, Inc.

University of North Carolina at Chapel Hill

Bill & Melinda Gates Foundation

Sugen Incorporated

Yi Xia

Jacob J Plattner

Paul Andrew Barsanti

Annette Olga Walter

Yong-Kang Zhang

Paul A Renhowe

Evan Lloyd Davies

Weibo Wang

Robert Toms Jacobs

Gabriel Antoniu Slup

Luis Miguel Avila

David Hughes

Rajeshwar Singh

Michael Richard Kevin Alley

David Duhl

Tsutomu Akama

Kuo-Hsiung Lee

Zheng-Yu Yang

Kirk R Maples

Vincent S Hernandez

Virginia J Sanders

Hongyan Guo

Stephen J Baker

Yasheen Zhou

James Nieman

Xianfeng Li

Daitao Chen

Yvonne Freund

Sheng-Chu Kuo

Daniel J Poon

Savithri Ramurthy

Cynthia Shafer

Christopher McBride

Sabina Pecchi

Sharadha Subramanian

Ding Zhou

Chung Chen Wei

Xiaodong Lin

Zhi-Jie Ni

Rustum S Boyce

Ping Huang

Tinya Abrams

Timothy D Machajewski

Kenneth F Bastow

Barry Haskell Levine

Abran Q Costales

James G Phillips

Kris Mendenhall

Nathan Brammeier

Charles Z Ding

Kathy Jingyuan Cao

Rashmi Sharma

Megan C Phillips

Rustum Boyce

Christopher S Lunde

Ashton E Diaz

Marcelo Sales

Xiaosong Lu

Matthew Perry

Alice C Rico

Liana Marie Lagniton

Ryan N Constantine

Huchen Zhou

Teresa E Pick

Kelly Wayman

Maureen McKenna

William R Antonios-McCrea

Guofeng Jia

Rahim Mohammad

Eliza Jazan

Sreekanth Ramachandran

Sheno-Chu Kuo

Kris G Mendenhull

Zhenhai Gao

Kristin Brinner

Brandon M Doughan

Jie-Kai Cheng

David Dibble

Ligong Ou

Neerja Saraswat

X Michael Wang

Nathan M Brammeier

Tinya J Abrams

Annette O Walter

Kris G Mendenhall

James A Niemann

Xiasong Lu

James A Nieman

El Mehdi Keramane

Minh Ha

Tsutoma Akama

Michael Richard Alley

A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle awhen the bottom slip is in an unset position.

Downhole tool with bottom composite slip

A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle ain a range of 10 degrees to 20 degrees when the bottom slip is in an unset position.

Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.

Boron-containing small molecules

One-piece slip

Compounds and methods of treating anti-inflammatory conditions are disclosed.

Boron-containing small molecules as anti-inflammatory agents

This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.

Trisubstituted boron-containing molecules

Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof: 

Substituted pyrazole and triazole compounds as KSP inhibitors

The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula (I).

Indole and benzimidazole derivatives

Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

Tetrahydrocarboline compounds as anticancer agents

Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.

2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses of the compounds. The compounds of the invention have the following general formula: 

Substituted imidazole compounds as KSP inhibitors

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Yi Xia