Rexahn Pharmaceuticals, Inc.

Pliva Hrvatska D.o.o.

Cephalon, Inc.

Xenon Pharmaceuticals Inc.

Yi Wang

Deog Joong Kim

Petra Dieterich

Jean-Francois Carniaux

Eliezer Falb

Jonathan Cummins

Haifeng Yin

Leigh Andre Pearcey

Vikram Chandrakant Purohit

Marina Ratkaj

Jasna Dogan

Tomislav Biljan

Maja Matanovic Skugor

Sara Morasi Pipercic

Leonid Metsger

Daniel Levy

George C Morton

Shawn P Allwein

Ronen Ben-David

Joseph A Sclafani

Michael A Christie

Orel Yosef Mizrahi

Gerard C Rosse

Linli He

Nelson G Landmesser

Partha S Mudipalli

Harlan F Reese

Jian Chen

Mina Gadelrab Dimitri

Graciela Noemi Gershon

Vikrain Chandrakant Purohit

The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.

Processes and intermediates for the preparation of Pimavanserin

The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes. 

This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Asymmetric synthesis of funapide

Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3 -hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one(13, RX-3117) and its intermediates are described. 

Process for the preparation of 4-amino 1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one

Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described. 

Process or the preparation of 4-amino 1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-Enyl)-1H-pyrimidin-2-one

Process for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one

This application relates to tricyclic compounds of Formula I: including all stereoisomeric forms, all mixtures of stereoisomeric forms, and salts of these compounds. This application also relates to compositions comprising compounds of Formula I, stereoisomeric forms, all mixtures of stereoisomeric forms, and salts thereof and uses therefor.

Tricyclic derivatives and their pharmaceutical use and compositions

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Chester Springs, PA, United States of America

Yi Wang