Tusimple, Inc.

Araxes Pharma LLC

Kura Oncology, Inc.

University of Michigan

Qualcomm Incorporated

Citrix Systems, Inc.

Tellabs Operations, Inc.

Tellabs San Jose, Inc.

Yi Wang

Yi Luo

Pingda Ren

Liansheng Li

Tao Wu

Ke Xu

Xiaoling Han

Liu Liu

Ruiliang Zhang

Lindong Sun

Yi Liu

Jun Feng

Yuan Liu

Wentao Zhu

Jolanta Grembecka

Tomasz Cierpicki

Dmitry Borkin

Szymon Klossowski

Jonathan Pollock

Bolun Zhang

Panqu Wang

Sameer Wadhwa

Charles A Price

Gilbert Levesque

Malyadri Jaladanki

Lennart Karl-Axel Mathe

Lennart Karl Mathe

Chunping Song

Hector Ivan Oporta

Satyendra Tiwari

Daragh Padraic MacGabhann

Vijay Kumar Venkatachalam

Debashis Dey

Prakash Giri

Ji Hoon Hyun

Francis Burrows

Linda V Kessler

Jingchuan Zhang, I

Alana K Borum

Jiaqi Liu

A system is disclosed including at least one memory including computer program instructions, which when executed by at least one processor, cause the system to at least generate, based on a plurality of images from a camera, a first map including a first plurality of features; generate, based on data from a light ranging sensor, a second map including a second plurality of features; and determine, based on a comparison of the first plurality of features and the second plurality of features, a position of the first map relative to the second map. A corresponding method and non-transitory computer-readable medium are also provided.

Feature matching and correspondence refinement and 3D submap position refinement system and method for centimeter precision localization using camera-based submap and LiDAR-based global map

Devices, systems and methods for remote safe driving of an autonomous vehicle are described. One exemplary method includes selecting, based on a classification of driver behavior, at least one of a set of driving actions and transmitting, to a vehicle over a secure communication channel, the at least one of the set of driving actions.

Remote safe driving methods and systems

Disclosed are devices, systems and methods for securing wireless communications between a remote monitor center and a vehicle by using redundancy measures to increase the robustness of the system. In some embodiments, a system may include redundant communication channels, deploy redundant hardware and software stacks to enable switching to a backup in an emergency situation, and employ hypervisors at both the remote monitor center and the vehicle to monitor hardware and software resources and perform integrity checks. In other embodiments, message digests based on a cryptographic hash function and a plurality of predetermined commands are generated at both the remote monitor center and the vehicle, and compared to ensure the continuing integrity of the wireless communication system.

Security architecture for a real-time remote vehicle monitoring system

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R, L, L, L, A, A, A, A, G, G, E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer

An apparatus is provided to comprise: at least one processor and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus to: receive, from an electronic control unit of a vehicle, a test result comprising a result of a self test performed by the electronic control unit; analyze the received test result to determine a vehicle status, the vehicle status comprising a status indicator and status information to be included in a report; periodically transmit, to a remote system according to a first time period, a report including the vehicle status, a duration of the first time period being dependent on the vehicle status; receive, from the remote system, a control command; and in response to the control command being received, implement the control command.

Monitoring system for autonomous vehicle operation

Described are devices, systems and methods for real-time remote control of vehicles with high redundancy. In some embodiments, two copies of at least one control command are received using two different wireless communication protocols, and are compared. The at least one control command is executed when the two copies are in agreement, but is rejected when the two copies differ. In other embodiments, additional wireless communication protocols may exist to provide a redundant mode of communication when one of the two different wireless communication protocols are unavailable. In yet other embodiments, redundant GPS units may be used to determine availability of any of the communication protocols, and relevant control commands may be downloaded in advance to circumvent a lack of coverage.

Real-time remote control of vehicles with high redundancy

The present disclosure provides methods for treating hematological malignancies and Ewings sarcoma using menin inhibitors. Compositions for use in these methods are also provided.

Methods for treating hematological malignancies and Ewing's sarcoma

The present disclosure provides methods of inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins with compositions of Formula (II-A). The methods are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin. Compositions of Formula (II-A) for use in these methods are also provided. 

Substituted inhibitors of menin-MLL and methods of use

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R, R, R, R, R, R, R, R, R, L, L, E, mand mare as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided. 

Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS

Power supply circuit having low quiescent current for a bypass mode. One example power supply circuit generally includes a transistor; a switching node coupled to a source of the transistor; a power supply rail; a capacitor having a first terminal coupled to the power supply rail and having a second terminal coupled to the switching node; a gate driver having an output coupled to a gate of the transistor, having a first power input coupled to the power supply rail, and having a second power input coupled to the switching node; logic having a first input coupled to the first terminal of the capacitor, having a second input coupled to the second terminal of the capacitor, and having a first output; and a pullup circuit having a control input coupled to a second output of the logic and having an output coupled to the gate of the transistor.

Power supply circuit with low quiescent current in bypass mode

The present disclosure provides compounds of Formula (I-A) for inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compounds are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin. 

Bridged bicyclic inhibitors of menin-MLL and methods of use

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R, R, R, R, R, R, R, R, R, L, L, L, E, m, mand * are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Covalent inhibitors of KRAS

Described are devices, systems and methods for real-time remote control of vehicles with high redundancy. In some embodiments, two copies of at least one control command are received using two different wireless communication protocols, and are compared. The at least one control command is executed when the two copies are in agreement, but is rejected when the two copies differ. In other embodiments, additional wireless communication protocols may exist to provide a redundant mode of communication when one of the two different wireless communication protocols are unavailable. In yet other embodiments, redundant GPS units may be used to determine availability of any of the communication protocols, and relevant control commands may be downloaded in advance to circumvent the lack of coverage.

Disclosed are devices, systems and methods for a monitoring system for autonomous vehicle operation. In some embodiments, a vehicle may perform self-tests, generate a report based on the results, and transmit it to a remote monitor center over one or both of a high-speed channel for regular data transfers or a reliable channel for emergency situations. In other embodiments, the remote monitor center may determine that immediate intervention is required, and may transmit a control command with high priority, which when received by the vehicle, is implemented and overrides any local commands being processed. In yet other embodiments, the control command with high priority is selected from a small group of predetermined control commands the remote monitor center may issue.

Growing community of inventors

San Diego, CA, United States of America

Yi Wang