Other

Yi Wan

Yan Wang

Lei Gao

Chang Chen

Yuying Zhang

Xinhua Qiao

Provided are a method, target and application for NO accumulation to decrease invasiveness of; achieving NO accumulation by means of external NO donors or disruption of internal NO metabolism in an environment whereis growing or being cultured, in order to decrease production byof the invasion factor pyocyanin. Utilizing even micro-quantities of NO can significantly inhibitPCN (PCN synthesis down 82% with 60 &#x3bc;M SNP treatment); by inhibiting NO reductase, an enzyme related to NO metabolism, PCN synthesis can be significantly inhibited (the PAO1-&#x394;nor strain has 84% PCN reduction). Using NO donors or inhibiting enzymes involved inNO metabolism as a means of combating bacterial infectious disease does not affect the body's normal microflora like traditional antibiotics.

Growing community of inventors

Xi'an, China

Yi Wan