University of Texas System

University of North Texas

Yi Shi

Kenneth J Balkus, Jr

Anthony J Di Pasqua

Imalka S Munaweera

Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (Ho) and dysprosium-164 (Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

Growing community of inventors

Fort Worth, TX, United States of America

Yi Shi