Janssen Pharmaceutica Nv

Yi Liu

Christopher M Flores

Ning Qin

Mark J Macielag

Scott L Dax

Mark Andrew Youngman

James J McNally

Donald William Ludovici

Christopher A Teleha

Jay M Matthews

Kenneth M Wells

Ronald K Russell

Michele C Jetter

Raymond W Colburn

Shawn T Branum

Scott C Youells

Laura M Reaney

Michael P Neeper

Tasha Hutchinson

Mary Lou Lubin

Laura M Andraka

James J Mcnally

Laura M Reany

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R, R, R, and Rare defined herein.

Sulfonamides as TRPM8 modulators

It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

Compositions and methods for identifying modulators of TRPV2

The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.

Canine cold- and menthol-sensitive receptor 1

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Spring House, PA, United States of America

Yi Liu