Ucb Pharma, S.a.

Amgen Inc.

Other

Translate Bio, Inc.

Accurus Biosciences, Inc.

Yi Lin Zhang

Andrew George Popplewell

Kenneth William Walker

Gunasekaran Kannan

Agnes Eva Hamburger

Jackie Zeqi Sheng

Zhulun Wang

Xiaoshan Min

Murielle M Veniant-Ellison

YuMei Xiong

Jie Tang

Grant Shimamoto

Ralph Adams

Richard Evan Gelinas

Mitra Choudhury Singhal

Michael W Heartlein

Frank DeRosa

Shrirang Karve

Alastair David Griffiths Lawson

Bryan D Lemon

Stevan Graham Shaw

Andrew Malcolm Nesbitt

Diana Shpektor

Marissa Mock

Zarna Patel

Jinkang Wang

Haishan Lin

Ashish Sarode

Hansj&ouml;rg Eibl

Rebecca L Goldman

GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Growth differentiation factor 15 (GDF-15) polypeptides

Provided are anti-CD47 antibodies or fragments thereof that can bind to the extra cellular domain of the CD47 protein. The antibodies or fragments thereof can effectively block the interaction between human CD47 and its ligand SIRP alpha and enhance the phagocytosis activity of macrophages to engulf cancer cells. Some of these antibodies or fragments do not induce in vitro hemagglutination and therefore can be suitably used as therapeutic agents with reduced off-target effects.

Blocking antibodies against CD47 and methods of use thereof

Disclosed are cationic lipids which are compounds of Formula I. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins. 

Cationic lipids comprising a steroidal moiety

Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R, R, L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions. 

Poly(phosphoesters) for delivery of nucleic acids

The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.

Process of preparing mRNA-loaded lipid nanoparticles

Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Growth differentiation factor 15 (GDF-15) constructs

The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Antibody molecules having specificity for human OX40

The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Methods for treating IL-6 mediated diseases with antibody molecules specific for IL-6

Methods for making antibody molecules having specificity for human IL-6

DNA encoding antibody molecules having specificity for human IL-6

Growing community of inventors

Woodside, CA, United States of America

Yi Lin Zhang