Ethicon, Gmbh

Ethicon Endo-surgery, Inc.

Cilag International Gmbh

Case Western Reserve University

Yi-Lan Wang

Leo B Kriksunov

Guanghui Zhang

Matthew C Miller

Aron O Zingman

Bret William Smith

Thomas W Lytle, Iv

Xintian Ming

Kreena Rajeev Modi

Joseph F Zavatsky

Charles J Scheib

Chad Paul Boudreaux

Israel Nur

Edward A Rhad

Stephen J Balek

Ying Sun

Erez Ilan

Gerard H Llanos

Dwayne Lee Looney

Chunlin Yang

Matthew D Holcomb

Jerry Silver

Omri Faingold

Tamar Auerbach-Nevo

Bradley T Lang

Jared M Cregg

Donald F Wilson, Jr

Tali Negreanu-Gilboa

Thomas Weindl

Xuejun Jay Liu

Wilai Kosol

Jerry Yan

Hadas Alperin

Thomas W Iv Lytle

Kreena R Modi

Joseph Zavatsky

Kreena Modi

The present invention is directed to multi-layered wound dressings having a carrier layer, at least two sublayers, wherein each sublayer contains at least one reactive, cross-linkable component and the at least two reactive, cross-linkable components are co-reactive with the other and at least one reactive, cross-linkable has a protective leaving group and a buffering salt agent.

Sealant dressing with protected reactive components

An expandable biodegradable hemostatic matrix comprised of oxidized cellulose, and having a density ranging from about 0.8 to about 1.2 gr/cmis disclosed herein. The matrix may be expandable to at least 3 times its original volume within 4 sec upon contact with an aqueous solution room temperature. Further disclosed are methods for making the hemostatic matrix as well as method of treating a wound.

Expandable hemostat composed of oxidized cellulose

The present invention relates to a hemostatic absorbable composition, comprising: a flowable plurality of separate aggregates each comprising: a plurality of absorbable carrier particles coated on a surface thereof by a plurality of smaller particles comprising an absorbable supplemental hemostasis-promoting agent. In some embodiments, the absorbable carrier particles comprise gelatin or collagen, and the supplemental hemostasis-promoting agent comprises oxidized cellulose, oxidized regenerated cellulose, carboxylic oxidized cellulose, carboxylic oxidized regenerated cellulose, thrombin, or tranexamic acid.

Hemostatic composite aggregate materials having surface enriched with hemostatis-promoting agents

The present invention is directed to a hemostatic material comprising a compacted, hemostatic aggregates of cellulosic fibers. In some aspects, the hemostatic material further includes additives, such as carboxymethyl cellulose (CMC) or other polysaccharides, calcium salts, anti-infective agents, hemostasis promoting agents, gelatin, collagen, or combinations thereof. In another aspect, the present invention is directed to a method of making the hemostatic materials described above by compacting a cellulosic-based material into hemostatic aggregates. In another aspect, the present invention is directed to a method of treating a wound by applying hemostatic materials described above onto and/or into the wound of a patient.

Compacted hemostatic cellulosic aggregates

The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.

Hemostatic paste having surface enriched with hemostasis-promoting agents and devices for delivery

The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.

Multi-compartment pre-filled mixing syringes with bypass

The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices.

Methods and devices for co-delivery of liquid and powdered hemostats and sealants

The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based 'Traditional Chinese Medicinal' product and devices incorporating such agents for the delivery thereof to bleeding wounds.

Hemostatic preparation containing an extract of golden moss

The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analogue sequence. The scaffold is preferably hemostatic, such as a natural or genetically engineered absorbable polymer, a synthetic absorbable polymer, or combinations thereof. The natural or genetically engineered absorbable polymers can be selected from the group consisting of a protein, a polysaccharide, or combinations thereof.

Procoagulant peptides and their derivatives and uses therefor

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Belle Mead, NJ, United States of America

Yi-Lan Wang